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Nature AOPNature AOPA pre-existing hydrophobic collapse in the unfolded state of an ultrafast folding protein

RNA-templated DNA repair

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex

A direct link of the Mos?MAPK pathway to Erp1/Emi2 in meiotic arrest of Xenopuslaevis eggs

A new perceptual illusion reveals mechanisms of sensory decoding

UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis

Phosphorylation of Erp1 by p90rsk is required for cytostatic factor arrest in Xenopus laevis eggs

Template switching during break-induced replication

Neuroscience: The brain's garbage men

Opposing LSD1 complexes function in developmental gene activation and repression programmes

TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

Cell tracing shows the contribution of the yolk sac to adult haematopoiesis

Damage to the prefrontal cortex increases utilitarian moral judgements

Unproductive splicing of SR genes associated with highly conserved and ultraconserved DNA elements

Nature AOPNature AOPImage statistics and the perception of surface qualities

Visual perception: A gloss on surface properties

A pre-existing hydrophobic collapse in the unfolded state of an ultrafast folding protein

RNA-templated DNA repair

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex

A direct link of the Mos?MAPK pathway to Erp1/Emi2 in meiotic arrest of Xenopuslaevis eggs

UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis

Phosphorylation of Erp1 by p90rsk is required for cytostatic factor arrest in Xenopus laevis eggs

Template switching during break-induced replication

Neuroscience: The brain's garbage men

Cell tracing shows the contribution of the yolk sac to adult haematopoiesis

Nature AOPNature AOPImage statistics and the perception of surface qualities

Visual perception: A gloss on surface properties

A pre-existing hydrophobic collapse in the unfolded state of an ultrafast folding protein

RNA-templated DNA repair

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex

A direct link of the Mos?MAPK pathway to Erp1/Emi2 in meiotic arrest of Xenopuslaevis eggs

UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis

Phosphorylation of Erp1 by p90rsk is required for cytostatic factor arrest in Xenopus laevis eggs

Template switching during break-induced replication

Neuroscience: The brain's garbage men

Cell tracing shows the contribution of the yolk sac to adult haematopoiesis

Nature AOPNature AOPA type III effector ADP-ribosylates RNA-binding proteins and quells plant immunity

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

A chromatin link that couples cell division to root epidermis patterning in Arabidopsis

A positive feedback mechanism governs the polarity and motion of motile cilia

Chitin induces accumulation in tissue of innate immune cells associated with allergy

PTC124 targets genetic disorders caused by nonsense mutations

Chemical biology: Ignore the nonsense

Image statistics and the perception of surface qualities

Visual perception: A gloss on surface properties

A pre-existing hydrophobic collapse in the unfolded state of an ultrafast folding protein

RNA-templated DNA repair

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex

A direct link of the Mos?MAPK pathway to Erp1/Emi2 in meiotic arrest of Xenopuslaevis eggs

UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis

Phosphorylation of Erp1 by p90rsk is required for cytostatic factor arrest in Xenopus laevis eggs

Template switching during break-induced replication

Neuroscience: The brain's garbage men

Cell tracing shows the contribution of the yolk sac to adult haematopoiesis

Nature AOPNature AOPA type III effector ADP-ribosylates RNA-binding proteins and quells plant immunity

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

A chromatin link that couples cell division to root epidermis patterning in Arabidopsis

A positive feedback mechanism governs the polarity and motion of motile cilia

Chitin induces accumulation in tissue of innate immune cells associated with allergy

PTC124 targets genetic disorders caused by nonsense mutations

Chemical biology: Ignore the nonsense

Image statistics and the perception of surface qualities

Visual perception: A gloss on surface properties

A pre-existing hydrophobic collapse in the unfolded state of an ultrafast folding protein

RNA-templated DNA repair

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex

A direct link of the Mos?MAPK pathway to Erp1/Emi2 in meiotic arrest of Xenopuslaevis eggs

UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis

Phosphorylation of Erp1 by p90rsk is required for cytostatic factor arrest in Xenopus laevis eggs

Template switching during break-induced replication

Neuroscience: The brain's garbage men

Cell tracing shows the contribution of the yolk sac to adult haematopoiesis

Nature AOPNature AOPA type III effector ADP-ribosylates RNA-binding proteins and quells plant immunity

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

A chromatin link that couples cell division to root epidermis patterning in Arabidopsis

A positive feedback mechanism governs the polarity and motion of motile cilia

Chitin induces accumulation in tissue of innate immune cells associated with allergy

PTC124 targets genetic disorders caused by nonsense mutations

Chemical biology: Ignore the nonsense

Image statistics and the perception of surface qualities

Visual perception: A gloss on surface properties

A pre-existing hydrophobic collapse in the unfolded state of an ultrafast folding protein

RNA-templated DNA repair

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex

Template switching during break-induced replication

Nature AOPNature AOPA type III effector ADP-ribosylates RNA-binding proteins and quells plant immunity

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

A chromatin link that couples cell division to root epidermis patterning in Arabidopsis

A positive feedback mechanism governs the polarity and motion of motile cilia

Chitin induces accumulation in tissue of innate immune cells associated with allergy

PTC124 targets genetic disorders caused by nonsense mutations

Chemical biology: Ignore the nonsense

Image statistics and the perception of surface qualities

Visual perception: A gloss on surface properties

A pre-existing hydrophobic collapse in the unfolded state of an ultrafast folding protein

RNA-templated DNA repair

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex

Template switching during break-induced replication

Nature AOPNature AOPRecovery of learning and memory is associated with chromatin remodelling

Atomic structures of amyloid cross-? spines reveal varied steric zippers

Control of alternative RNA splicing and gene expression by eukaryotic riboswitches

Bypassing genomic imprinting allows seed development

The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation

Behavioural neuroscience: Down memory lane

A type III effector ADP-ribosylates RNA-binding proteins and quells plant immunity

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

A chromatin link that couples cell division to root epidermis patterning in Arabidopsis

A positive feedback mechanism governs the polarity and motion of motile cilia

Chitin induces accumulation in tissue of innate immune cells associated with allergy

PTC124 targets genetic disorders caused by nonsense mutations

Chemical biology: Ignore the nonsense

Image statistics and the perception of surface qualities

Visual perception: A gloss on surface properties

A pre-existing hydrophobic collapse in the unfolded state of an ultrafast folding protein

RNA-templated DNA repair

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex

Template switching during break-induced replication

Nature AOPNature AOPRecovery of learning and memory is associated with chromatin remodelling

Atomic structures of amyloid cross-? spines reveal varied steric zippers

Control of alternative RNA splicing and gene expression by eukaryotic riboswitches

Bypassing genomic imprinting allows seed development

The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation

Behavioural neuroscience: Down memory lane

A type III effector ADP-ribosylates RNA-binding proteins and quells plant immunity

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

A chromatin link that couples cell division to root epidermis patterning in Arabidopsis

A positive feedback mechanism governs the polarity and motion of motile cilia

Chitin induces accumulation in tissue of innate immune cells associated with allergy

PTC124 targets genetic disorders caused by nonsense mutations

Chemical biology: Ignore the nonsense

Image statistics and the perception of surface qualities

Visual perception: A gloss on surface properties

A pre-existing hydrophobic collapse in the unfolded state of an ultrafast folding protein

RNA-templated DNA repair

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex

Template switching during break-induced replication

Nature AOPNature AOPPHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

Transcriptional coactivator PGC-1? integrates the mammalian clock and energy metabolism

Alp7/TACC is a crucial target in Ran-GTPase-dependent spindle formation in fission yeast

Recovery of learning and memory is associated with chromatin remodelling

Atomic structures of amyloid cross-? spines reveal varied steric zippers

Control of alternative RNA splicing and gene expression by eukaryotic riboswitches

Bypassing genomic imprinting allows seed development

The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation

Behavioural neuroscience: Down memory lane

A type III effector ADP-ribosylates RNA-binding proteins and quells plant immunity

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

A chromatin link that couples cell division to root epidermis patterning in Arabidopsis

Image statistics and the perception of surface qualities

Visual perception: A gloss on surface properties

RNA-templated DNA repair

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex

Nature AOPNature AOPPHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

Transcriptional coactivator PGC-1? integrates the mammalian clock and energy metabolism

Alp7/TACC is a crucial target in Ran-GTPase-dependent spindle formation in fission yeast

Recovery of learning and memory is associated with chromatin remodelling

Atomic structures of amyloid cross-? spines reveal varied steric zippers

Control of alternative RNA splicing and gene expression by eukaryotic riboswitches

Bypassing genomic imprinting allows seed development

The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation

Behavioural neuroscience: Down memory lane

A type III effector ADP-ribosylates RNA-binding proteins and quells plant immunity

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

A chromatin link that couples cell division to root epidermis patterning in Arabidopsis

Image statistics and the perception of surface qualities

Visual perception: A gloss on surface properties

RNA-templated DNA repair

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex

Nature AOPNature AOPEnergy-dependent regulation of cell structure by AMP-activated protein kinase

SUMOylation regulates kainate-receptor-mediated synaptic transmission

Neuroscience: Wrestling with SUMO

PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

Transcriptional coactivator PGC-1? integrates the mammalian clock and energy metabolism

Alp7/TACC is a crucial target in Ran-GTPase-dependent spindle formation in fission yeast

Recovery of learning and memory is associated with chromatin remodelling

Atomic structures of amyloid cross-? spines reveal varied steric zippers

Control of alternative RNA splicing and gene expression by eukaryotic riboswitches

Bypassing genomic imprinting allows seed development

The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation

Behavioural neuroscience: Down memory lane

A type III effector ADP-ribosylates RNA-binding proteins and quells plant immunity

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

A chromatin link that couples cell division to root epidermis patterning in Arabidopsis

Image statistics and the perception of surface qualities

Visual perception: A gloss on surface properties

RNA-templated DNA repair

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex

Nature AOPNature AOPPrion recognition elements govern nucleation, strain specificity and species barriers

Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases

The hottest planet

Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands

Experimental and theoretical study of mitotic spindle orientation

Energy-dependent regulation of cell structure by AMP-activated protein kinase

SUMOylation regulates kainate-receptor-mediated synaptic transmission

Neuroscience: Wrestling with SUMO

PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

Transcriptional coactivator PGC-1? integrates the mammalian clock and energy metabolism

Alp7/TACC is a crucial target in Ran-GTPase-dependent spindle formation in fission yeast

Atomic structures of amyloid cross-? spines reveal varied steric zippers

Control of alternative RNA splicing and gene expression by eukaryotic riboswitches

Bypassing genomic imprinting allows seed development

The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation

A type III effector ADP-ribosylates RNA-binding proteins and quells plant immunity

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

RNA-templated DNA repair

Nature AOPNature AOPPrion recognition elements govern nucleation, strain specificity and species barriers

Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases

The hottest planet

Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands

Experimental and theoretical study of mitotic spindle orientation

Energy-dependent regulation of cell structure by AMP-activated protein kinase

SUMOylation regulates kainate-receptor-mediated synaptic transmission

Neuroscience: Wrestling with SUMO

PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

Transcriptional coactivator PGC-1? integrates the mammalian clock and energy metabolism

Alp7/TACC is a crucial target in Ran-GTPase-dependent spindle formation in fission yeast

Atomic structures of amyloid cross-? spines reveal varied steric zippers

Control of alternative RNA splicing and gene expression by eukaryotic riboswitches

Bypassing genomic imprinting allows seed development

The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation

A type III effector ADP-ribosylates RNA-binding proteins and quells plant immunity

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

RNA-templated DNA repair

Nature AOPNature AOPPrion recognition elements govern nucleation, strain specificity and species barriers

Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases

The hottest planet

Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands

Experimental and theoretical study of mitotic spindle orientation

Energy-dependent regulation of cell structure by AMP-activated protein kinase

SUMOylation regulates kainate-receptor-mediated synaptic transmission

Neuroscience: Wrestling with SUMO

PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

Transcriptional coactivator PGC-1? integrates the mammalian clock and energy metabolism

Alp7/TACC is a crucial target in Ran-GTPase-dependent spindle formation in fission yeast

Atomic structures of amyloid cross-? spines reveal varied steric zippers

Control of alternative RNA splicing and gene expression by eukaryotic riboswitches

Bypassing genomic imprinting allows seed development

The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation

A type III effector ADP-ribosylates RNA-binding proteins and quells plant immunity

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

RNA-templated DNA repair

Nature AOPNature AOPPrion recognition elements govern nucleation, strain specificity and species barriers

Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases

The hottest planet

Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands

Experimental and theoretical study of mitotic spindle orientation

Energy-dependent regulation of cell structure by AMP-activated protein kinase

SUMOylation regulates kainate-receptor-mediated synaptic transmission

Neuroscience: Wrestling with SUMO

PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

Transcriptional coactivator PGC-1? integrates the mammalian clock and energy metabolism

Alp7/TACC is a crucial target in Ran-GTPase-dependent spindle formation in fission yeast

Atomic structures of amyloid cross-? spines reveal varied steric zippers

Control of alternative RNA splicing and gene expression by eukaryotic riboswitches

Bypassing genomic imprinting allows seed development

The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation

A type III effector ADP-ribosylates RNA-binding proteins and quells plant immunity

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

RNA-templated DNA repair

Nature AOPNature AOPMicroRNA silencing through RISC recruitment of eIF6

West Nile virus emergence and large-scale declines of North American bird populations

8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins

Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation

Disease ecology: The silence of the robins

Prion recognition elements govern nucleation, strain specificity and species barriers

Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases

The hottest planet

Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands

Experimental and theoretical study of mitotic spindle orientation

Energy-dependent regulation of cell structure by AMP-activated protein kinase

PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

Transcriptional coactivator PGC-1? integrates the mammalian clock and energy metabolism

Atomic structures of amyloid cross-? spines reveal varied steric zippers

Control of alternative RNA splicing and gene expression by eukaryotic riboswitches

The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

Nature AOPNature AOPEnergy-dependent regulation of cell structure by AMP-activated protein kinase

SUMOylation regulates kainate-receptor-mediated synaptic transmission

Neuroscience: Wrestling with SUMO

PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

Transcriptional coactivator PGC-1? integrates the mammalian clock and energy metabolism

Alp7/TACC is a crucial target in Ran-GTPase-dependent spindle formation in fission yeast

Recovery of learning and memory is associated with chromatin remodelling

Atomic structures of amyloid cross-? spines reveal varied steric zippers

Control of alternative RNA splicing and gene expression by eukaryotic riboswitches

Bypassing genomic imprinting allows seed development

The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation

Behavioural neuroscience: Down memory lane

A type III effector ADP-ribosylates RNA-binding proteins and quells plant immunity

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

A chromatin link that couples cell division to root epidermis patterning in Arabidopsis

Image statistics and the perception of surface qualities

Visual perception: A gloss on surface properties

RNA-templated DNA repair

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex

Nature AOPNature AOPChromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

Macrophage-specific PPAR? controls alternative activation and improves insulin resistance

Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors

MicroRNA silencing through RISC recruitment of eIF6

West Nile virus emergence and large-scale declines of North American bird populations

8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins

Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation

Disease ecology: The silence of the robins

Prion recognition elements govern nucleation, strain specificity and species barriers

Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases

The hottest planet

Disulphide-isomerase-enabled shedding of tumour-associated NKG2D ligands

Experimental and theoretical study of mitotic spindle orientation

Energy-dependent regulation of cell structure by AMP-activated protein kinase

PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

Transcriptional coactivator PGC-1? integrates the mammalian clock and energy metabolism

Atomic structures of amyloid cross-? spines reveal varied steric zippers

Control of alternative RNA splicing and gene expression by eukaryotic riboswitches

The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

Nature AOPNature AOPLateral habenula as a source of negative reward signals in dopamine neurons

Mechanism of coupled folding and binding of an intrinsically disordered protein

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

Macrophage-specific PPAR? controls alternative activation and improves insulin resistance

Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors

MicroRNA silencing through RISC recruitment of eIF6

West Nile virus emergence and large-scale declines of North American bird populations

8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins

Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation

Disease ecology: The silence of the robins

Prion recognition elements govern nucleation, strain specificity and species barriers

The hottest planet

Energy-dependent regulation of cell structure by AMP-activated protein kinase

PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation

Nature AOPNature AOPLateral habenula as a source of negative reward signals in dopamine neurons

Mechanism of coupled folding and binding of an intrinsically disordered protein

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

Macrophage-specific PPAR? controls alternative activation and improves insulin resistance

Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors

MicroRNA silencing through RISC recruitment of eIF6

West Nile virus emergence and large-scale declines of North American bird populations

8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins

Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation

Disease ecology: The silence of the robins

Prion recognition elements govern nucleation, strain specificity and species barriers

The hottest planet

Energy-dependent regulation of cell structure by AMP-activated protein kinase

PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation

Nature AOPNature AOPGenome-wide association study identifies novel breast cancer susceptibility loci

Lateral habenula as a source of negative reward signals in dopamine neurons

Mechanism of coupled folding and binding of an intrinsically disordered protein

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

Macrophage-specific PPAR? controls alternative activation and improves insulin resistance

Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors

MicroRNA silencing through RISC recruitment of eIF6

West Nile virus emergence and large-scale declines of North American bird populations

8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins

Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation

Disease ecology: The silence of the robins

Prion recognition elements govern nucleation, strain specificity and species barriers

The hottest planet

Energy-dependent regulation of cell structure by AMP-activated protein kinase

PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation

Nature AOPNature AOPGenome-wide association study identifies novel breast cancer susceptibility loci

Lateral habenula as a source of negative reward signals in dopamine neurons

Mechanism of coupled folding and binding of an intrinsically disordered protein

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

Macrophage-specific PPAR? controls alternative activation and improves insulin resistance

Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors

MicroRNA silencing through RISC recruitment of eIF6

West Nile virus emergence and large-scale declines of North American bird populations

8-oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins

Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation

Disease ecology: The silence of the robins

Prion recognition elements govern nucleation, strain specificity and species barriers

The hottest planet

Energy-dependent regulation of cell structure by AMP-activated protein kinase

PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans

The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation

Nature AOPNature AOPGene-specific control of inflammation by TLR-induced chromatin modifications

The menthol receptor TRPM8 is the principal detector of environmental cold

miRNAs control gene expression in the single-cell alga Chlamydomonas reinhardtii

Genome-wide association study identifies novel breast cancer susceptibility loci

Lateral habenula as a source of negative reward signals in dopamine neurons

Mechanism of coupled folding and binding of an intrinsically disordered protein

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

Macrophage-specific PPAR? controls alternative activation and improves insulin resistance

MicroRNA silencing through RISC recruitment of eIF6

West Nile virus emergence and large-scale declines of North American bird populations

Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation

Disease ecology: The silence of the robins

The hottest planet

Energy-dependent regulation of cell structure by AMP-activated protein kinase

Nature AOPNature AOPGene-specific control of inflammation by TLR-induced chromatin modifications

The menthol receptor TRPM8 is the principal detector of environmental cold

miRNAs control gene expression in the single-cell alga Chlamydomonas reinhardtii

Genome-wide association study identifies novel breast cancer susceptibility loci

Lateral habenula as a source of negative reward signals in dopamine neurons

Mechanism of coupled folding and binding of an intrinsically disordered protein

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

Macrophage-specific PPAR? controls alternative activation and improves insulin resistance

MicroRNA silencing through RISC recruitment of eIF6

West Nile virus emergence and large-scale declines of North American bird populations

Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation

Disease ecology: The silence of the robins

The hottest planet

Energy-dependent regulation of cell structure by AMP-activated protein kinase

Nature AOPNature AOPProbabilistic reasoning by neurons

Gene-specific control of inflammation by TLR-induced chromatin modifications

The menthol receptor TRPM8 is the principal detector of environmental cold

miRNAs control gene expression in the single-cell alga Chlamydomonas reinhardtii

Genome-wide association study identifies novel breast cancer susceptibility loci

Lateral habenula as a source of negative reward signals in dopamine neurons

Mechanism of coupled folding and binding of an intrinsically disordered protein

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

Macrophage-specific PPAR? controls alternative activation and improves insulin resistance

MicroRNA silencing through RISC recruitment of eIF6

West Nile virus emergence and large-scale declines of North American bird populations

Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation

Disease ecology: The silence of the robins

The hottest planet

Energy-dependent regulation of cell structure by AMP-activated protein kinase

Nature AOPNature AOPTreatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2

Generation of germline-competent induced pluripotent stem cells

In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state

A microRNA component of the p53 tumour suppressor network

Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1? transcription coactivator

Probabilistic reasoning by neurons

Gene-specific control of inflammation by TLR-induced chromatin modifications

The menthol receptor TRPM8 is the principal detector of environmental cold

miRNAs control gene expression in the single-cell alga Chlamydomonas reinhardtii

Genome-wide association study identifies novel breast cancer susceptibility loci

Lateral habenula as a source of negative reward signals in dopamine neurons

Mechanism of coupled folding and binding of an intrinsically disordered protein

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

Macrophage-specific PPAR? controls alternative activation and improves insulin resistance

MicroRNA silencing through RISC recruitment of eIF6

Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation

Energy-dependent regulation of cell structure by AMP-activated protein kinase

Nature AOPNature AOPTreatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2

Generation of germline-competent induced pluripotent stem cells

In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state

A microRNA component of the p53 tumour suppressor network

Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1? transcription coactivator

Probabilistic reasoning by neurons

Gene-specific control of inflammation by TLR-induced chromatin modifications

The menthol receptor TRPM8 is the principal detector of environmental cold

miRNAs control gene expression in the single-cell alga Chlamydomonas reinhardtii

Genome-wide association study identifies novel breast cancer susceptibility loci

Lateral habenula as a source of negative reward signals in dopamine neurons

Mechanism of coupled folding and binding of an intrinsically disordered protein

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

Macrophage-specific PPAR? controls alternative activation and improves insulin resistance

MicroRNA silencing through RISC recruitment of eIF6

Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation

Energy-dependent regulation of cell structure by AMP-activated protein kinase

Nature AOPNature AOP?Rejuvenation? protects neurons in mouse models of Parkinson?s disease

Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2

Generation of germline-competent induced pluripotent stem cells

In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state

A microRNA component of the p53 tumour suppressor network

Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1? transcription coactivator

Probabilistic reasoning by neurons

Gene-specific control of inflammation by TLR-induced chromatin modifications

The menthol receptor TRPM8 is the principal detector of environmental cold

miRNAs control gene expression in the single-cell alga Chlamydomonas reinhardtii

Genome-wide association study identifies novel breast cancer susceptibility loci

Lateral habenula as a source of negative reward signals in dopamine neurons

Mechanism of coupled folding and binding of an intrinsically disordered protein

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

Macrophage-specific PPAR? controls alternative activation and improves insulin resistance

MicroRNA silencing through RISC recruitment of eIF6

Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation

Energy-dependent regulation of cell structure by AMP-activated protein kinase

Nature AOPNature AOP?Rejuvenation? protects neurons in mouse models of Parkinson?s disease

Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2

Generation of germline-competent induced pluripotent stem cells

In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state

A microRNA component of the p53 tumour suppressor network

Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1? transcription coactivator

Probabilistic reasoning by neurons

Gene-specific control of inflammation by TLR-induced chromatin modifications

The menthol receptor TRPM8 is the principal detector of environmental cold

miRNAs control gene expression in the single-cell alga Chlamydomonas reinhardtii

Genome-wide association study identifies novel breast cancer susceptibility loci

Lateral habenula as a source of negative reward signals in dopamine neurons

Mechanism of coupled folding and binding of an intrinsically disordered protein

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

Macrophage-specific PPAR? controls alternative activation and improves insulin resistance

MicroRNA silencing through RISC recruitment of eIF6

Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation

Energy-dependent regulation of cell structure by AMP-activated protein kinase

Nature AOPNature AOPProtective and therapeutic role for ?B-crystallin in autoimmune demyelination

Nature AOPNature AOPAntitumour drugs impede DNA uncoiling by topoisomerase I

Ambra1 regulates autophagy and development of the nervous system

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

Rhythmic growth explained by coincidence between internal and external cues

Intronic microRNA precursors that bypass Drosha processing

Structural basis for substrate loading in bacterial RNA polymerase

Structural basis for transcription elongation by bacterial RNA polymerase

CD1d?lipid-antigen recognition by the semi-invariant NKT T-cell receptor

Hebbian STDP in mushroom bodies facilitates the synchronous flow of olfactory information in locusts

IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

Immunology: How a T cell sees sugar

Transvascular delivery of small interfering RNA to the central nervous system

Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J

Protective and therapeutic role for ?B-crystallin in autoimmune demyelination

A gigantic bird-like dinosaur from the Late Cretaceous of China

?Rejuvenation? protects neurons in mouse models of Parkinson?s disease

Generation of germline-competent induced pluripotent stem cells

In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state

A microRNA component of the p53 tumour suppressor network

Probabilistic reasoning by neurons

Gene-specific control of inflammation by TLR-induced chromatin modifications

The menthol receptor TRPM8 is the principal detector of environmental cold

miRNAs control gene expression in the single-cell alga Chlamydomonas reinhardtii

Genome-wide association study identifies novel breast cancer susceptibility loci

Lateral habenula as a source of negative reward signals in dopamine neurons

Nature AOPNature AOPDAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

Structure-based activity prediction for an enzyme of unknown function

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

Variants conferring risk of atrial fibrillation on chromosome 4q25

Nature AOPNature AOPThe JAZ family of repressors is the missing link in jasmonate signalling

Structural insight into filament formation by mammalian septins

JAZ repressor proteins are targets of the SCFCOI1 complex during jasmonate signalling

Common effector processing mediates cell-specific responses to stimuli

Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis

A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene

Morphological evolution through multiple cis-regulatory mutations at a single gene

Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase

Electronic spin transport and spin precession in single graphene layers at room temperature

IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro

Identification of the transforming EML4?ALK fusion gene in non-small-cell lung cancer

A flagellin-induced complex of the receptor FLS2 and BAK1 initiates plant defence

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

Structure-based activity prediction for an enzyme of unknown function

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

Synthetic biology: Designs for life

Non-transcriptional control of DNA replication by c-Myc

Ambra1 regulates autophagy and development of the nervous system

Hebbian STDP in mushroom bodies facilitates the synchronous flow of olfactory information in locusts

IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

Protective and therapeutic role for ?B-crystallin in autoimmune demyelination

A gigantic bird-like dinosaur from the Late Cretaceous of China

Gene-specific control of inflammation by TLR-induced chromatin modifications

Nature AOPNature AOPA functional circuit underlying male sexual behaviour in the female mouse brain

Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome

LKB1 modulates lung cancer differentiation and metastasis

Behavioural neurobiology: Females can also be from Mars

A central integrator of transcription networks in plant stress and energy signalling

Break-induced replication and telomerase-independent telomere maintenance require Pol32

A sequence-based variation map of 8.27 million SNPs in inbred mouse strains

A transglutaminase homologue as a condensation catalyst in antibiotic assembly lines

Small self-RNA generated by RNase L amplifies antiviral innate immunity

Indirect radiative forcing of climate change through ozone effects on the land-carbon sink

A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord

The JAZ family of repressors is the missing link in jasmonate signalling

Structural insight into filament formation by mammalian septins

JAZ repressor proteins are targets of the SCFCOI1 complex during jasmonate signalling

IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro

Structure-based activity prediction for an enzyme of unknown function

Synthetic biology: Designs for life

Ambra1 regulates autophagy and development of the nervous system

Hebbian STDP in mushroom bodies facilitates the synchronous flow of olfactory information in locusts

A gigantic bird-like dinosaur from the Late Cretaceous of China

Gene-specific control of inflammation by TLR-induced chromatin modifications

Nature AOPNature AOPCrystal structure of the MgtE Mg2 transporter

Loss of integrin ?v?8 on dendritic cells causes autoimmunity and colitis in mice

The structural basis for activation of plant immunity by bacterial effector protein AvrPto

Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1

An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus

Antidepressant binding site in a bacterial homologue of neurotransmitter transporters

A functional circuit underlying male sexual behaviour in the female mouse brain

Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome

Behavioural neurobiology: Females can also be from Mars

A central integrator of transcription networks in plant stress and energy signalling

A sequence-based variation map of 8.27 million SNPs in inbred mouse strains

Structural insight into filament formation by mammalian septins

IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro

Synthetic biology: Designs for life

Ambra1 regulates autophagy and development of the nervous system

A gigantic bird-like dinosaur from the Late Cretaceous of China

Gene-specific control of inflammation by TLR-induced chromatin modifications

Nature AOPNature AOPEnzymatic capture of an extrahelical thymine in the search for uracil in DNA

ZEITLUPE is a circadian photoreceptor stabilized by GIGANTEA in blue light

Mechanism of chloride interaction with neurotransmitter:sodium symporters

Crystal structure of the MgtE Mg2 transporter

Loss of integrin ?v?8 on dendritic cells causes autoimmunity and colitis in mice

The structural basis for activation of plant immunity by bacterial effector protein AvrPto

Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1

An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus

Antidepressant binding site in a bacterial homologue of neurotransmitter transporters

A functional circuit underlying male sexual behaviour in the female mouse brain

Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome

Behavioural neurobiology: Females can also be from Mars

A central integrator of transcription networks in plant stress and energy signalling

A sequence-based variation map of 8.27 million SNPs in inbred mouse strains

Structural insight into filament formation by mammalian septins

IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro

Synthetic biology: Designs for life

Ambra1 regulates autophagy and development of the nervous system

A gigantic bird-like dinosaur from the Late Cretaceous of China

Gene-specific control of inflammation by TLR-induced chromatin modifications

Nature AOPNature AOPEnzymatic capture of an extrahelical thymine in the search for uracil in DNA

ZEITLUPE is a circadian photoreceptor stabilized by GIGANTEA in blue light

Mechanism of chloride interaction with neurotransmitter:sodium symporters

Crystal structure of the MgtE Mg2 transporter

Loss of integrin ?v?8 on dendritic cells causes autoimmunity and colitis in mice

The structural basis for activation of plant immunity by bacterial effector protein AvrPto

Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1

An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus

Antidepressant binding site in a bacterial homologue of neurotransmitter transporters

A functional circuit underlying male sexual behaviour in the female mouse brain

Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome

Behavioural neurobiology: Females can also be from Mars

A central integrator of transcription networks in plant stress and energy signalling

A sequence-based variation map of 8.27 million SNPs in inbred mouse strains

Structural insight into filament formation by mammalian septins

IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro

Synthetic biology: Designs for life

Ambra1 regulates autophagy and development of the nervous system

A gigantic bird-like dinosaur from the Late Cretaceous of China

Gene-specific control of inflammation by TLR-induced chromatin modifications

Nature AOPNature AOPEnzymatic capture of an extrahelical thymine in the search for uracil in DNA

ZEITLUPE is a circadian photoreceptor stabilized by GIGANTEA in blue light

Mechanism of chloride interaction with neurotransmitter:sodium symporters

Crystal structure of the MgtE Mg2 transporter

Loss of integrin ?v?8 on dendritic cells causes autoimmunity and colitis in mice

The structural basis for activation of plant immunity by bacterial effector protein AvrPto

Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1

An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus

Antidepressant binding site in a bacterial homologue of neurotransmitter transporters

A functional circuit underlying male sexual behaviour in the female mouse brain

Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome

Behavioural neurobiology: Females can also be from Mars

A central integrator of transcription networks in plant stress and energy signalling

A sequence-based variation map of 8.27 million SNPs in inbred mouse strains

Structural insight into filament formation by mammalian septins

IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro

Synthetic biology: Designs for life

Ambra1 regulates autophagy and development of the nervous system

A gigantic bird-like dinosaur from the Late Cretaceous of China

Gene-specific control of inflammation by TLR-induced chromatin modifications

Nature AOPNature AOPThe structural basis of yeast prion strain variants

MicroRNA control of Nodal signalling

Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU

Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity

The grapevine genome sequence suggests ancestral hexaploidization in major angiosperm phyla

Structural basis of Dscam isoform specificity

Differential Notch signalling distinguishes neural stem cells from intermediate progenitors

UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation

IgH class switching and translocations use a robust non-classical end-joining pathway

Enzymatic capture of an extrahelical thymine in the search for uracil in DNA

ZEITLUPE is a circadian photoreceptor stabilized by GIGANTEA in blue light

Mechanism of chloride interaction with neurotransmitter:sodium symporters

Loss of integrin ?v?8 on dendritic cells causes autoimmunity and colitis in mice

The structural basis for activation of plant immunity by bacterial effector protein AvrPto

Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide

Structural insight into filament formation by mammalian septins

Synthetic biology: Designs for life

Ambra1 regulates autophagy and development of the nervous system

A gigantic bird-like dinosaur from the Late Cretaceous of China

Gene-specific control of inflammation by TLR-induced chromatin modifications

Nature AOPNature AOPPlasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide

Crystal structure of T4 endonuclease VII resolving a Holliday junction

The structural basis of Holliday junction resolution by T7 endonuclease I

Genetic variation in a human odorant receptor alters odour perception

Autoimmune disease: Skin deep but complex

A histone H3 lysine 27 demethylase regulates animal posterior development

Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1

Snapshots of nuclear pore complexes in action captured by cryo-electron tomography

Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors

Light adaptation in cone vision involves switching between receptor and post-receptor sites

Structural basis for AMP binding to mammalian AMP-activated protein kinase

Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2

The grapevine genome sequence suggests ancestral hexaploidization in major angiosperm phyla

Structural basis of Dscam isoform specificity

Differential Notch signalling distinguishes neural stem cells from intermediate progenitors

UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

IgH class switching and translocations use a robust non-classical end-joining pathway

Enzymatic capture of an extrahelical thymine in the search for uracil in DNA

ZEITLUPE is a circadian photoreceptor stabilized by GIGANTEA in blue light

Mechanism of chloride interaction with neurotransmitter:sodium symporters

Loss of integrin ?v?8 on dendritic cells causes autoimmunity and colitis in mice

Structural insight into filament formation by mammalian septins

Synthetic biology: Designs for life

Ambra1 regulates autophagy and development of the nervous system

A gigantic bird-like dinosaur from the Late Cretaceous of China

Gene-specific control of inflammation by TLR-induced chromatin modifications

Nature AOPNature AOPPhagocyte-derived catecholamines enhance acute inflammatory injury

Neanderthals in central Asia and Siberia

A translocation signal for delivery of oomycete effector proteins into host plant cells

Tumour invasion and metastasis initiated by microRNA-10b in breast cancer

Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive

Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway

Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation

Protein-based peptide-bond formation by aminoacyl-tRNA protein transferase

Functional architecture of the retromer cargo-recognition complex

Recognition of DNA damage by the Rad4 nucleotide excision repair protein

Anaerobic oxidation of short-chain hydrocarbons by marine sulphate-reducing bacteria

Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide

Crystal structure of T4 endonuclease VII resolving a Holliday junction

The structural basis of Holliday junction resolution by T7 endonuclease I

Autoimmune disease: Skin deep but complex

A histone H3 lysine 27 demethylase regulates animal posterior development

Snapshots of nuclear pore complexes in action captured by cryo-electron tomography

Light adaptation in cone vision involves switching between receptor and post-receptor sites

UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

Mechanism of chloride interaction with neurotransmitter:sodium symporters

Synthetic biology: Designs for life

Ambra1 regulates autophagy and development of the nervous system

A gigantic bird-like dinosaur from the Late Cretaceous of China

Gene-specific control of inflammation by TLR-induced chromatin modifications

Nature AOPNature AOPIdentification of stem cells in small intestine and colon by marker gene Lgr5

High-resolution structure prediction and the crystallographic phase problem

PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans

Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells

Computational biology: Protein predictions

SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron

The amniote primitive streak is defined by epithelial cell intercalation before gastrulation

Nucleation and growth mechanism of ferroelectric domain-wall motion

Architectural and mechanistic insights into an EHD ATPase involved in membrane remodelling

Regulation of cell cycle progression and gene expression by H2A deubiquitination

Neanderthals in central Asia and Siberia

A translocation signal for delivery of oomycete effector proteins into host plant cells

Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive

Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation

Protein-based peptide-bond formation by aminoacyl-tRNA protein transferase

Functional architecture of the retromer cargo-recognition complex

Anaerobic oxidation of short-chain hydrocarbons by marine sulphate-reducing bacteria

Synthetic biology: Designs for life

Nature AOPNature AOPCharacterizing the cancer genome in lung adenocarcinoma

Human CtIP promotes DNA end resection

Element-selective imaging of atomic columns in a crystal using STEM and EELS

Hedgehog regulates smoothened activity by inducing a conformational switch

Identification of Tim4 as a phosphatidylserine receptor

BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module

Legionella pneumophila proteins that regulate Rab1 membrane cycling

Crystal structure of the human ?2 adrenergic G-protein-coupled receptor

An epigenetic activation role of Piwi and a Piwi-associated piRNA in Drosophila melanogaster

Neural substrates of awakening probed with optogenetic control of hypocretin neurons

An essential role for a CD36-related receptor in pheromone detection in Drosophila

High-resolution structure prediction and the crystallographic phase problem

Computational biology: Protein predictions

SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron

Synthetic biology: Designs for life

Nature AOPNature AOPIntrinsic motions along an enzymatic reaction trajectory

A hierarchy of timescales in protein dynamics is linked to enzyme catalysis

Adaptive immunity maintains occult cancer in an equilibrium state

Cancer: Immune pact with the enemy

Producing primate embryonic stem cells by somatic cell nuclear transfer

Host?parasite ?Red Queen? dynamics archived in pond sediment

Methane oxidation by an extremely acidophilic bacterium of the phylum Verrucomicrobia

The major Vibrio cholerae autoinducer and its role in virulence factor production

How kinesin waits between steps

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

Methanotrophy below pH?1 by a new Verrucomicrobia species

Stem cells: Primates join the club

Genotyping of Rhesus SCNT pluripotent stem cell lines

Enhanced biological carbon consumption in a high CO2 ocean

The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA

Innate versus learned odour processing in the mouse olfactory bulb

Characterizing the cancer genome in lung adenocarcinoma

Human CtIP promotes DNA end resection

Element-selective imaging of atomic columns in a crystal using STEM and EELS

Synthetic biology: Designs for life

Nature AOPNature AOPReconstitution of a microtubule plus-end tracking system in vitro

Coevolution with viruses drives the evolution of bacterial mutation rates

RNA-mediated epigenetic programming of a genome-rearrangement pathway

Distinct physiological states of Plasmodium falciparum in malaria-infected patients

Initiation of zebrafish haematopoiesis by the TATA-box-binding protein-related factor Trf3

RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination

Intrinsic motions along an enzymatic reaction trajectory

A hierarchy of timescales in protein dynamics is linked to enzyme catalysis

Adaptive immunity maintains occult cancer in an equilibrium state

Cancer: Immune pact with the enemy

Host?parasite ?Red Queen? dynamics archived in pond sediment

Methane oxidation by an extremely acidophilic bacterium of the phylum Verrucomicrobia

The major Vibrio cholerae autoinducer and its role in virulence factor production

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

Methanotrophy below pH?1 by a new Verrucomicrobia species

The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA

Characterizing the cancer genome in lung adenocarcinoma

Nature AOPNature AOPCrude-oil biodegradation via methanogenesis in subsurface petroleum reservoirs

A receptor that mediates the post-mating switch in Drosophila reproductive behaviour

Three-dimensional atomic-scale structure of size-selected gold nanoclusters

RNA-mediated epigenetic programming of a genome-rearrangement pathway

Nature AOPNature AOPReprogramming of human somatic cells to pluripotency with defined factors

Host genome surveillance for retrotransposons by transposon-derived proteins

Behavioural report of single neuron stimulation in somatosensory cortex

Sparse optical microstimulation in barrel cortex drives learned behaviour in freely moving mice

Crude-oil biodegradation via methanogenesis in subsurface petroleum reservoirs

A receptor that mediates the post-mating switch in Drosophila reproductive behaviour

Three-dimensional atomic-scale structure of size-selected gold nanoclusters

RNA-mediated epigenetic programming of a genome-rearrangement pathway

Nature AOPNature AOPHistone H2AX-dependent GABAA receptor regulation of stem cell proliferation

Lethargus is a Caenorhabditis elegans sleep-like state

Predicting expression patterns from regulatory sequence in Drosophila segmentation

Host genome surveillance for retrotransposons by transposon-derived proteins

Nature AOPNature AOPArc-parallel flow in the mantle wedge beneath Costa Rica and Nicaragua

Bacterial carbon processing by generalist species in the coastal ocean

Cell cycle control of centromeric repeat transcription and heterochromatin assembly

A fundamental avian wing-stroke provides a new perspective on the evolution of flight

The coming acceleration of global population ageing

The adaptive significance of temperature-dependent sex determination in a reptile

Drosophila Pgc protein inhibits P-TEFb recruitment to chromatin in primordial germ cells

NLRX1 is a regulator of mitochondrial antiviral immunity

Lethargus is a Caenorhabditis elegans sleep-like state

Predicting expression patterns from regulatory sequence in Drosophila segmentation

Nature AOPNature AOPResistance to therapy caused by intragenic deletion in BRCA2

Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

Haematopoietic stem cell release is regulated by circadian oscillations

Formation and branch migration of Holliday junctions mediated by eukaryotic recombinases

Cohesin mediates transcriptional insulation by CCCTC-binding factor

A modular switch for spatial Ca2 selectivity in the calmodulin regulation of CaV channels

The X-ray crystal structure of RNA polymerase from Archaea

A role for adult TLX-positive neural stem cells in learning and behaviour

Arc-parallel flow in the mantle wedge beneath Costa Rica and Nicaragua

Bacterial carbon processing by generalist species in the coastal ocean

Cell cycle control of centromeric repeat transcription and heterochromatin assembly

A fundamental avian wing-stroke provides a new perspective on the evolution of flight

The coming acceleration of global population ageing

Drosophila Pgc protein inhibits P-TEFb recruitment to chromatin in primordial germ cells

Nature AOPNature AOPPreserving cell shape under environmental stress

Identification of a serotonin/glutamate receptor complex implicated in psychosis

A peptide deformylase?ribosome complex reveals mechanism of nascent chain processing

Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons

Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

Proline-catalysed Mannich reactions of acetaldehyde

Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets

Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning

Regulation of progenitor cell proliferation and granulocyte function by microRNA-223

Translational control of the innate immune response through IRF-7

Gamete formation without meiosis in Arabidopsis

Transcriptional repression mediated by repositioning of genes to the nuclear lamina

Facultative cheater mutants reveal the genetic complexity of cooperation in social amoebae

Resistance to therapy caused by intragenic deletion in BRCA2

Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers

Haematopoietic stem cell release is regulated by circadian oscillations

Arc-parallel flow in the mantle wedge beneath Costa Rica and Nicaragua

Nature AOPNature AOPFollowing translation by single ribosomes one codon at a time

Isolation of an active step I spliceosome and composition of its RNP core

Broad phylogenomic sampling improves resolution of the animal tree of life

Memory CD4 T cells emerge from effector T-cell progenitors

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

Identifying natural images from human brain activity

Biodiversity and biogeography of phages in modern stromatolites and thrombolites

Localization and functionality of microsporidian iron?sulphur cluster assembly proteins

A skin microRNA promotes differentiation by repressing ?stemness?

The Drosophila pheromone cVA activates a sexually dimorphic neural circuit

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

CO2 regulator SLAC1 and its homologues are essential for anion homeostasis in plant cells

Dendritic cell PAR1?S1P3 signalling couples coagulation and inflammation

SLAC1 is required for plant guard cell S-type anion channel function in stomatal signalling

Preserving cell shape under environmental stress

Proline-catalysed Mannich reactions of acetaldehyde

Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning

Translational control of the innate immune response through IRF-7

Transcriptional repression mediated by repositioning of genes to the nuclear lamina

Haematopoietic stem cell release is regulated by circadian oscillations

Nature AOPNature AOPControl of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

The genome of the model beetle and pest Tribolium castaneum

REST maintains self-renewal and pluripotency of embryonic stem cells

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

Kemp elimination catalysts by computational enzyme design

Hydatellaceae are water lilies with gymnospermous tendencies

Chromatin dynamics during epigenetic reprogramming in the mouse germ line

Integration of growth and specification in chick wing digit-patterning

Variations in DNA elucidate molecular networks that cause disease

Genetics of gene expression and its effect on disease

Lateral presynaptic inhibition mediates gain control in an olfactory circuit

Tumour maintenance is mediated by eNOS

A neural representation of depth from motion parallax in macaque visual cortex

NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration

Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1

Functional metagenomic profiling of nine biomes

Sophisticated particle-feeding in a large Early Cambrian crustacean

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

SAR11 marine bacteria require exogenous reduced sulphur for growth

Following translation by single ribosomes one codon at a time

Isolation of an active step I spliceosome and composition of its RNP core

Broad phylogenomic sampling improves resolution of the animal tree of life

Localization and functionality of microsporidian iron?sulphur cluster assembly proteins

The Drosophila pheromone cVA activates a sexually dimorphic neural circuit

CO2 regulator SLAC1 and its homologues are essential for anion homeostasis in plant cells

Dendritic cell PAR1?S1P3 signalling couples coagulation and inflammation

SLAC1 is required for plant guard cell S-type anion channel function in stomatal signalling

Proline-catalysed Mannich reactions of acetaldehyde

Haematopoietic stem cell release is regulated by circadian oscillations

Nature AOPNature AOPA deadenylation negative feedback mechanism governs meiotic metaphase arrest

Imaging of Rab5 activity identifies essential regulators for phagosome maturation

Discrete fixed-resolution representations in visual working memory

Genetic variation in human NPY expression affects stress response and emotion

LNA-mediated microRNA silencing in non-human primates

Retinotopic order in the absence of axon competition

TGF-?-induced Foxp3 inhibits TH17 cell differentiation by antagonizing ROR?t function

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

The genome of the model beetle and pest Tribolium castaneum

REST maintains self-renewal and pluripotency of embryonic stem cells

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

Kemp elimination catalysts by computational enzyme design

Hydatellaceae are water lilies with gymnospermous tendencies

Chromatin dynamics during epigenetic reprogramming in the mouse germ line

Integration of growth and specification in chick wing digit-patterning

Lateral presynaptic inhibition mediates gain control in an olfactory circuit

NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration

Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1

Sophisticated particle-feeding in a large Early Cambrian crustacean

Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

SAR11 marine bacteria require exogenous reduced sulphur for growth

Isolation of an active step I spliceosome and composition of its RNP core

Broad phylogenomic sampling improves resolution of the animal tree of life

Nature AOPNature AOPEvolution of metal hyperaccumulation required cis-regulatory changes and triplication of HMA4

Human metabolic phenotype diversity and its association with diet and blood pressure

The genomic and epidemiological dynamics of human influenza A virus

Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors

Vascular normalization in Rgs5-deficient tumours promotes immune destruction

Chromatin decouples promoter threshold from dynamic range

Free choice activates a decision circuit between frontal and parietal cortex

Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins

Nucleosome organization in the Drosophila genome

Functional genomic screen reveals genes involved in lipid-droplet formation and utilization

BCR?ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

Insect olfactory receptors are heteromeric ligand-gated ion channels

Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels

Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes

Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes

Upper intestinal lipids trigger a gut?brain?liver axis to regulate glucose production

A deadenylation negative feedback mechanism governs meiotic metaphase arrest

Imaging of Rab5 activity identifies essential regulators for phagosome maturation

Discrete fixed-resolution representations in visual working memory

Genetic variation in human NPY expression affects stress response and emotion

TGF-?-induced Foxp3 inhibits TH17 cell differentiation by antagonizing ROR?t function

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

The genome of the model beetle and pest Tribolium castaneum

REST maintains self-renewal and pluripotency of embryonic stem cells

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

Kemp elimination catalysts by computational enzyme design

Hydatellaceae are water lilies with gymnospermous tendencies

Lateral presynaptic inhibition mediates gain control in an olfactory circuit

Nature AOPNature AOPNeural substrates of vocalization feedback monitoring in primate auditory cortex

Cladistic analysis of continuous modularized traits provides phylogenetic signals in Homo evolution

Essential role for Nix in autophagic maturation of erythroid cells

Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer

Dynamics of fat cell turnover in humans

Angiogenesis selectively requires the p110? isoform of PI3K to control endothelial cell migration

The Cl-/H antiporter ClC-7 is the primary chloride permeation pathway in lysosomes

RNA toxicity is a component of ataxin-3 degeneration in Drosophila

Chemical compass model of avian magnetoreception

Genetic evidence that FGFs have an instructive role in limb proximal?distal patterning

Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation

Single-stranded DNA-binding protein hSSB1 is critical for genomic stability

A novel route for ATP acquisition by the remnant mitochondria of Encephalitozoon cuniculi

Rapid cloning of high-affinity human monoclonal antibodies against influenza virus

3.88?� structure of cytoplasmic polyhedrosis virus by cryo-electron microscopy

HP1-? mobilization promotes chromatin changes that initiate the DNA damage response

NF-?B links innate immunity to the hypoxic response through transcriptional regulation of HIF-1?

Superconductivity at 43?K in an iron-based layered compound LaO1-xFxFeAs

Human cardiovascular progenitor cells develop from a KDR embryonic-stem-cell-derived population

Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling

Evolution of metal hyperaccumulation required cis-regulatory changes and triplication of HMA4

Human metabolic phenotype diversity and its association with diet and blood pressure

The genomic and epidemiological dynamics of human influenza A virus

Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors

Vascular normalization in Rgs5-deficient tumours promotes immune destruction

Chromatin decouples promoter threshold from dynamic range

Free choice activates a decision circuit between frontal and parietal cortex

Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins

Nucleosome organization in the Drosophila genome

Functional genomic screen reveals genes involved in lipid-droplet formation and utilization

Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes

Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes

Imaging of Rab5 activity identifies essential regulators for phagosome maturation

Discrete fixed-resolution representations in visual working memory

TGF-?-induced Foxp3 inhibits TH17 cell differentiation by antagonizing ROR?t function

REST maintains self-renewal and pluripotency of embryonic stem cells

Kemp elimination catalysts by computational enzyme design

Nature AOPNature AOPDynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution

Towards a transgenic model of Huntington?s disease in a non-human primate

Huntington's Disease: Genetics lends a hand

A two-tiered mechanism for stabilization and immobilization of E-cadherin

A myocardial lineage derives from Tbx18 epicardial cells

Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants

Hippocampus-independent phase precession in entorhinal grid cells

PML targeting eradicates quiescent leukaemia-initiating cells

Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia

Ultrasonic frogs show hyperacute phonotaxis to female courtship calls

Rapid strengthening of thalamo-amygdala synapses mediates cue?reward learning

IL-21 and TGF-? are required for differentiation of human TH17 cells

The branching programme of mouse lung development

An endogenous small interfering RNA pathway in Drosophila

Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation

Drosophila endogenous small RNAs bind to Argonaute?2 in somatic cells

Cytokinin and auxin interaction in root stem-cell specification during early embryogenesis

The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs

Global control of cell-cycle transcription by coupled CDK and network oscillators

Neural substrates of vocalization feedback monitoring in primate auditory cortex

Cladistic analysis of continuous modularized traits provides phylogenetic signals in Homo evolution

Essential role for Nix in autophagic maturation of erythroid cells

Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer

Dynamics of fat cell turnover in humans

Angiogenesis selectively requires the p110? isoform of PI3K to control endothelial cell migration

The Cl-/H antiporter ClC-7 is the primary chloride permeation pathway in lysosomes

RNA toxicity is a component of ataxin-3 degeneration in Drosophila

Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation

Single-stranded DNA-binding protein hSSB1 is critical for genomic stability

A novel route for ATP acquisition by the remnant mitochondria of Encephalitozoon cuniculi

Rapid cloning of high-affinity human monoclonal antibodies against influenza virus

HP1-? mobilization promotes chromatin changes that initiate the DNA damage response

NF-?B links innate immunity to the hypoxic response through transcriptional regulation of HIF-1?

Human cardiovascular progenitor cells develop from a KDR embryonic-stem-cell-derived population

Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling

The genomic and epidemiological dynamics of human influenza A virus

Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins

Functional genomic screen reveals genes involved in lipid-droplet formation and utilization

Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes

Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes

Nature AOPNature AOPDissecting direct reprogramming through integrative genomic analysis

Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate

Two-band superconductivity in LaFeAsO0.89F0.11 at very high magnetic fields

Analysis of a spatial orientation memory in Drosophila

Cortical control of a prosthetic arm for self-feeding

Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription

Hydrogen sulphide release to surface waters at the Precambrian/Cambrian boundary

Magnetic order close to superconductivity in the iron-based layered LaO1-xFxFeAs systems

Neuroscience: Brain control of a helping hand

Superconductivity at 43?K in SmFeAsO1-xFx

Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving

Modest stabilization by most hydrogen-bonded side-chain interactions in membrane proteins

Imaging the biogenesis of individual HIV-1 virions in live cells

Structural basis for EGFR ligand sequestration by Argos

Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype

Structural basis for the regulated protease and chaperone function of DegP

A phosphatase cascade by which rewarding stimuli control nucleosomal response

Translation factors promote the formation of two states of the closed-loop mRNP

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution

Towards a transgenic model of Huntington?s disease in a non-human primate

Huntington's disease: Genetics lends a hand

A two-tiered mechanism for stabilization and immobilization of E-cadherin

A myocardial lineage derives from Tbx18 epicardial cells

Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants

Hippocampus-independent phase precession in entorhinal grid cells

PML targeting eradicates quiescent leukaemia-initiating cells

Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia

Ultrasonic frogs show hyperacute phonotaxis to female courtship calls

Rapid strengthening of thalamo-amygdala synapses mediates cue?reward learning

IL-21 and TGF-? are required for differentiation of human TH17 cells

The branching programme of mouse lung development

An endogenous small interfering RNA pathway in Drosophila

Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

Drosophila endogenous small RNAs bind to Argonaute?2 in somatic cells

Cytokinin and auxin interaction in root stem-cell specification during early embryogenesis

The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs

Global control of cell-cycle transcription by coupled CDK and network oscillators

Neural substrates of vocalization feedback monitoring in primate auditory cortex

Cladistic analysis of continuous modularized traits provides phylogenetic signals in Homo evolution

Essential role for Nix in autophagic maturation of erythroid cells

Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer

Dynamics of fat cell turnover in humans

The Cl-/H antiporter ClC-7 is the primary chloride permeation pathway in lysosomes

RNA toxicity is a component of ataxin-3 degeneration in Drosophila

Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation

NF-?B links innate immunity to the hypoxic response through transcriptional regulation of HIF-1?

Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling

Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins

Nature AOPNature AOPImbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells

Positive feedback sharpens the anaphase switch

Environmental determinants of extinction selectivity in the fossil record

SMAD proteins control DROSHA-mediated microRNA maturation

Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia

An internal thermal sensor controlling temperature preference in Drosophila

Subtropical to boreal convergence of tree-leaf temperatures

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

Structural basis of specific tRNA aminoacylation by a small in vitro selected ribozyme

Volcanic carbon dioxide vents show ecosystem effects of ocean acidification

A BCS-like gap in the superconductor SmFeAsO0.85F0.15

Template-directed synthesis of a genetic polymer in a model protocell

Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage

IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis

Dissecting direct reprogramming through integrative genomic analysis

Analysis of a spatial orientation memory in Drosophila

Cortical control of a prosthetic arm for self-feeding

Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription

Neuroscience: Brain control of a helping hand

Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving

Modest stabilization by most hydrogen-bonded side-chain interactions in membrane proteins

Imaging the biogenesis of individual HIV-1 virions in live cells

Structural basis for EGFR ligand sequestration by Argos

Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype

Translation factors promote the formation of two states of the closed-loop mRNP

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution

A myocardial lineage derives from Tbx18 epicardial cells

Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants

Hippocampus-independent phase precession in entorhinal grid cells

PML targeting eradicates quiescent leukaemia-initiating cells

Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia

Rapid strengthening of thalamo-amygdala synapses mediates cue?reward learning

IL-21 and TGF-? are required for differentiation of human TH17 cells

Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient

Cytokinin and auxin interaction in root stem-cell specification during early embryogenesis

Neural substrates of vocalization feedback monitoring in primate auditory cortex

Essential role for Nix in autophagic maturation of erythroid cells

RNA toxicity is a component of ataxin-3 degeneration in Drosophila

Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins

Nature AOPNature AOPcAMP signalling in mushroom bodies modulates temperature preference behaviour in Drosophila

Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors

Structure of a ?1-adrenergic G-protein-coupled receptor

Escape from adaptive conflict after duplication in an anthocyanin pathway gene

Evidence for the evolutionary nascence of a novel sex determination pathway in honeybees

Essential roles of PI(3)K?p110? in cell growth, metabolism and tumorigenesis

Switch of rhodopsin expression in terminally differentiated Drosophila sensory neurons

Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation

Mouse development with a single E2F activator

An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth

IRF4 addiction in multiple myeloma

Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart

Crystal structure of the ligand-free G-protein-coupled receptor opsin

A new class of homoserine lactone quorum-sensing signals

The role of the orbitofrontal cortex in the pursuit of happiness and more specific rewards

Control of segment number in vertebrate embryos

A unifying framework for dinitrogen fixation in the terrestrial biosphere

Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells

Positive feedback sharpens the anaphase switch

Environmental determinants of extinction selectivity in the fossil record

SMAD proteins control DROSHA-mediated microRNA maturation

Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia

An internal thermal sensor controlling temperature preference in Drosophila

Subtropical to boreal convergence of tree-leaf temperatures

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

Structural basis of specific tRNA aminoacylation by a small in vitro selected ribozyme

Volcanic carbon dioxide vents show ecosystem effects of ocean acidification

Template-directed synthesis of a genetic polymer in a model protocell

Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage

IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis

Dissecting direct reprogramming through integrative genomic analysis

Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription

Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving

Imaging the biogenesis of individual HIV-1 virions in live cells

A myocardial lineage derives from Tbx18 epicardial cells

IL-21 and TGF-? are required for differentiation of human TH17 cells

Essential role for Nix in autophagic maturation of erythroid cells

Nature AOPNature AOPSwitching on and off fear by distinct neuronal circuits

High-resolution mapping of meiotic crossovers and non-crossovers in yeast

Drosophila RNAi screen identifies host genes important for influenza virus replication

Crystal structure of the polymerase PAC?PB1N complex from an avian influenza H5N1 virus

Amygdala intercalated neurons are required for expression of fear extinction

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

A discontinuous hammerhead ribozyme embedded in a mammalian messenger RNA

Minimally invasive high-speed imaging of sarcomere contractile dynamics in mice and humans

Genome-scale DNA methylation maps of pluripotent and differentiated cells

Stress changes from the 2008 Wenchuan earthquake and increased hazard in the Sichuan basin

The cohesin ring concatenates sister DNA molecules

Structural basis for translation termination on the 70S ribosome

Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex

Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs

cAMP signalling in mushroom bodies modulates temperature preference behaviour in Drosophila

Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors

Structure of a ?1-adrenergic G-protein-coupled receptor

Escape from adaptive conflict after duplication in an anthocyanin pathway gene

Evidence for the evolutionary nascence of a novel sex determination pathway in honeybees

Essential roles of PI(3)K?p110? in cell growth, metabolism and tumorigenesis

Switch of rhodopsin expression in terminally differentiated Drosophila sensory neurons

Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation

Mouse development with a single E2F activator

An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth

A new class of homoserine lactone quorum-sensing signals

The role of the orbitofrontal cortex in the pursuit of happiness and more specific rewards

Control of segment number in vertebrate embryos

A unifying framework for dinitrogen fixation in the terrestrial biosphere

Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells

Positive feedback sharpens the anaphase switch

Environmental determinants of extinction selectivity in the fossil record

Subtropical to boreal convergence of tree-leaf temperatures

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

Structural basis of specific tRNA aminoacylation by a small in vitro selected ribozyme

IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis

IL-21 and TGF-? are required for differentiation of human TH17 cells

Nature AOPNature AOPA mechanism for asymmetric segregation of age during yeast budding

The structural basis for an essential subunit interaction in influenza virus RNA polymerase

Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspFU

Spatio-temporal correlations and visual signalling in a complete neuronal population

The pathogen protein EspFU hijacks actin polymerization using mimicry and multivalency

Cell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes

A blend of small molecules regulates both mating and development in Caenorhabditis elegans

Cryptochrome mediates light-dependent magnetosensitivity in Drosophila

Significant contribution of Archaea to extant biomass in marine subsurface sediments

Single-nucleotide mutation rate increases close to insertions/deletions in eukaryotes

Multipotent somatic stem cells contribute to the stem cell niche in the Drosophila testis

On the nature of partial agonism in the nicotinic receptor superfamily

Acetylcholine contributes through muscarinic receptors to attentional modulation in V1

Molecular basis of the copulatory plug polymorphism in Caenorhabditis elegans

Internal brain state regulates membrane potential synchrony in barrel cortex of behaving mice

The behaviour of Drosophila adult hindgut stem cells is controlled by Wnt and Hh signalling

Switching on and off fear by distinct neuronal circuits

Drosophila RNAi screen identifies host genes important for influenza virus replication

Crystal structure of the polymerase PAC?PB1N complex from an avian influenza H5N1 virus

Amygdala intercalated neurons are required for expression of fear extinction

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

A discontinuous hammerhead ribozyme embedded in a mammalian messenger RNA

Minimally invasive high-speed imaging of sarcomere contractile dynamics in mice and humans

Genome-scale DNA methylation maps of pluripotent and differentiated cells

Structural basis for translation termination on the 70S ribosome

Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex

MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs

cAMP signalling in mushroom bodies modulates temperature preference behaviour in Drosophila

Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors

Escape from adaptive conflict after duplication in an anthocyanin pathway gene

Essential roles of PI(3)K?p110? in cell growth, metabolism and tumorigenesis

Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation

Mouse development with a single E2F activator

An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth

A new class of homoserine lactone quorum-sensing signals

Environmental determinants of extinction selectivity in the fossil record

Nature AOPNature AOPThree-dimensional optical metamaterial with a negative refractive index

Strigolactone inhibition of shoot branching

Inhibition of shoot branching by new terpenoid plant hormones

Neural correlates, computation and behavioural impact of decision confidence

High bacterivory by the smallest phytoplankton in the North Atlantic Ocean

Earliest date for milk use in the Near East and southeastern Europe linked to cattle herding

Neurogenin 2 controls cortical neuron migration through regulation of Rnd2

RNA interference screen for human genes associated with West Nile virus infection

The virophage as a unique parasite of the giant mimivirus

Prolyl 4-hydroxylation regulates Argonaute 2 stability

UCP2 mediates ghrelin?s action on NPY/AgRP neurons by lowering free radicals

The impact of microRNAs on protein output

Widespread changes in protein synthesis induced by microRNAs

Metabolic gene regulation in a dynamically changing environment

Molecular architecture of native HIV-1 gp120 trimers

Direct observation of the mechanochemical coupling in myosin Va during processive movement

Large recurrent microdeletions associated with schizophrenia

Rare chromosomal deletions and duplications increase risk of schizophrenia

Nature AOPNature AOPIdentification of ALK as a major familial neuroblastoma predisposition gene

TMEM16A confers receptor-activated calcium-dependent chloride conductance

Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Regulatory networks define phenotypic classes of human stem cell lines

Structural insights into the evolutionary paths of oxylipin biosynthetic enzymes

ATP drives lamina propria TH17 cell differentiation

CDK targets Sae2 to control DNA-end resection and homologous recombination

The deubiquitinylation and localization of PTEN are regulated by a HAUSP?PML network

Counterintuitive carbon-to-nutrient coupling in an Arctic pelagic ecosystem

An intrinsic mechanism of corticogenesis from embryonic stem cells

Replication fork movement sets chromatin loop size and origin choice in mammalian cells

Modelling Myc inhibition as a cancer therapy

Heterochromatin links to centromeric protection by recruiting shugoshin

Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors

Type IV collagens regulate BMP signalling in Drosophila

Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance

T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance

Platelet-derived growth factor-? receptor activation is required for human cytomegalovirus infection

Three-dimensional optical metamaterial with a negative refractive index

Strigolactone inhibition of shoot branching

Inhibition of shoot branching by new terpenoid plant hormones

Neural correlates, computation and behavioural impact of decision confidence

High bacterivory by the smallest phytoplankton in the North Atlantic Ocean

Earliest date for milk use in the Near East and southeastern Europe linked to cattle herding

Neurogenin 2 controls cortical neuron migration through regulation of Rnd2

RNA interference screen for human genes associated with West Nile virus infection

The virophage as a unique parasite of the giant mimivirus

Prolyl 4-hydroxylation regulates Argonaute 2 stability

The impact of microRNAs on protein output

Widespread changes in protein synthesis induced by microRNAs

Metabolic gene regulation in a dynamically changing environment

Molecular architecture of native HIV-1 gp120 trimers

Direct observation of the mechanochemical coupling in myosin Va during processive movement

Large recurrent microdeletions associated with schizophrenia

Rare chromosomal deletions and duplications increase risk of schizophrenia

The structural basis for an essential subunit interaction in influenza virus RNA polymerase

Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B

Cell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes

A blend of small molecules regulates both mating and development in Caenorhabditis elegans

Single-nucleotide mutation rate increases close to insertions/deletions in eukaryotes

Multipotent somatic stem cells contribute to the stem cell niche in the Drosophila testis

Acetylcholine contributes through muscarinic receptors to attentional modulation in V1

Crystal structure of the polymerase PAC?PB1N complex from an avian influenza H5N1 virus

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

Mouse development with a single E2F activator

Nature AOPNature AOPIndividual differences in non-verbal number acuity correlate with maths achievement

UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism

Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1

The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix

Structure of the Tribolium castaneum telomerase catalytic subunit TERT

Structural basis for specific cleavage of Lys?63-linked polyubiquitin chains

Genes mirror geography within Europe

Structure of the 30S translation initiation complex

Structure of the guide-strand-containing argonaute silencing complex

In vivo reprogramming of adult pancreatic exocrine cells to ?-cells

Functional auditory hair cells produced in the mammalian cochlea by in utero gene transfer

S-nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons

A paracrine requirement for hedgehog signalling in cancer

Identification of ALK as a major familial neuroblastoma predisposition gene

TMEM16A confers receptor-activated calcium-dependent chloride conductance

Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Regulatory networks define phenotypic classes of human stem cell lines

Structural insights into the evolutionary paths of oxylipin biosynthetic enzymes

ATP drives lamina propria TH17 cell differentiation

CDK targets Sae2 to control DNA-end resection and homologous recombination

The deubiquitinylation and localization of PTEN are regulated by a HAUSP?PML network

Counterintuitive carbon-to-nutrient coupling in an Arctic pelagic ecosystem

An intrinsic mechanism of corticogenesis from embryonic stem cells

Replication fork movement sets chromatin loop size and origin choice in mammalian cells

Modelling Myc inhibition as a cancer therapy

Heterochromatin links to centromeric protection by recruiting shugoshin

Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors

Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance

T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance

Platelet-derived growth factor-? receptor activation is required for human cytomegalovirus infection

Three-dimensional optical metamaterial with a negative refractive index

Strigolactone inhibition of shoot branching

Inhibition of shoot branching by new terpenoid plant hormones

Neural correlates, computation and behavioural impact of decision confidence

High bacterivory by the smallest phytoplankton in the North Atlantic Ocean

Earliest date for milk use in the Near East and southeastern Europe linked to cattle herding

RNA interference screen for human genes associated with West Nile virus infection

Prolyl 4-hydroxylation regulates Argonaute 2 stability

Large recurrent microdeletions associated with schizophrenia

Rare chromosomal deletions and duplications increase risk of schizophrenia

Nature AOPNature AOPSae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

The pectoral fin of Panderichthys and the origin of digits

Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy

Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis

Acoel development indicates the independent evolution of the bilaterian mouth and anus

Self-renewal and expansion of single transplanted muscle stem cells

MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

CDK8 is a colorectal cancer oncogene that regulates ?-catenin activity

The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla

E2F1 represses ?-catenin transcription and is antagonized by both pRB and CDK8

Dual epithelial origin of vertebrate oral teeth

Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7

Concurrent nucleation of 16S folding and induced fit in 30S ribosome assembly

Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation

Structural insights into amino acid binding and gene control by a lysine riboswitch

Individual differences in non-verbal number acuity correlate with maths achievement

UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism

Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1

The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix

Structure of the Tribolium castaneum telomerase catalytic subunit TERT

Genes mirror geography within Europe

Structure of the guide-strand-containing argonaute silencing complex

In vivo reprogramming of adult pancreatic exocrine cells to ?-cells

Functional auditory hair cells produced in the mammalian cochlea by in utero gene transfer

Identification of ALK as a major familial neuroblastoma predisposition gene

TMEM16A confers receptor-activated calcium-dependent chloride conductance

Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

ATP drives lamina propria TH17 cell differentiation

CDK targets Sae2 to control DNA-end resection and homologous recombination

The deubiquitinylation and localization of PTEN are regulated by a HAUSP?PML network

Replication fork movement sets chromatin loop size and origin choice in mammalian cells

Modelling Myc inhibition as a cancer therapy

Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors

Earliest date for milk use in the Near East and southeastern Europe linked to cattle herding

Nature AOPNature AOPEarly origins and evolution of microRNAs and Piwi-interacting RNAs in animals

Squeezing and entanglement in a Bose?Einstein condensate

The essential role of the CopN protein in Chlamydia pneumoniae intracellular growth

Oligopotent stem cells are distributed throughout the mammalian ocular surface

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs

The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers

Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast

Activity-dependent regulation of inhibitory synapse development by Npas4

Promoter-driven splicing regulation in fission yeast

GILT is a critical host factor for Listeria monocytogenes infection

ROS3 is an RNA-binding protein required for DNA demethylation in Arabidopsis

Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks

Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing

The pectoral fin of Panderichthys and the origin of digits

Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy

Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis

Acoel development indicates the independent evolution of the bilaterian mouth and anus

Self-renewal and expansion of single transplanted muscle stem cells

MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla

Dual epithelial origin of vertebrate oral teeth

Concurrent nucleation of 16S folding and induced fit in 30S ribosome assembly

Structural insights into amino acid binding and gene control by a lysine riboswitch

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism

Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1

The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix

Genes mirror geography within Europe

Structure of the guide-strand-containing argonaute silencing complex

Identification of ALK as a major familial neuroblastoma predisposition gene

TMEM16A confers receptor-activated calcium-dependent chloride conductance

Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits

ATP drives lamina propria TH17 cell differentiation

The deubiquitinylation and localization of PTEN are regulated by a HAUSP?PML network

Nature AOPNature AOP53BP1 facilitates long-range DNA end-joining during V(D)J recombination

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

Sox18 induces development of the lymphatic vasculature in mice

Strong effect of dispersal network structure on ecological dynamics

The zinc-finger protein Zelda is a key activator of the early zygotic genome in Drosophila

Centrosome misorientation reduces stem cell division during ageing

The Phaeodactylum genome reveals the evolutionary history of diatom genomes

Direct control of paralysed muscles by cortical neurons

Entrained rhythmic activities of neuronal ensembles as perceptual memory of time interval

Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization

DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes

Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications

Generation of pluripotent stem cells from adult human testis

The ion pathway through the opened Na ,K -ATPase pump

Stereocilin-deficient mice reveal the origin of cochlear waveform distortions

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

Guarding the gateway to cortex with attention in visual thalamus

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1? production

Early origins and evolution of microRNAs and Piwi-interacting RNAs in animals

Squeezing and entanglement in a Bose?Einstein condensate

The essential role of the CopN protein in Chlamydia pneumoniae intracellular growth

Oligopotent stem cells are distributed throughout the mammalian ocular surface

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs

The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers

Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast

Activity-dependent regulation of inhibitory synapse development by Npas4

GILT is a critical host factor for Listeria monocytogenes infection

ROS3 is an RNA-binding protein required for DNA demethylation in Arabidopsis

Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks

The pectoral fin of Panderichthys and the origin of digits

Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy

Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis

Acoel development indicates the independent evolution of the bilaterian mouth and anus

Self-renewal and expansion of single transplanted muscle stem cells

MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation

Concurrent nucleation of 16S folding and induced fit in 30S ribosome assembly

Structural insights into amino acid binding and gene control by a lysine riboswitch

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Genes mirror geography within Europe

Structure of the guide-strand-containing argonaute silencing complex

TMEM16A confers receptor-activated calcium-dependent chloride conductance

Nature AOPNature AOPHITS-CLIP yields genome-wide insights into brain alternative RNA processing

Alternative isoform regulation in human tissue transcriptomes

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex

Coordinate control of synaptic-layer specificity and rhodopsins in photoreceptor neurons

Temporal identity in axonal target layer recognition

Structure of the intact PPAR-?–RXR-? nuclear receptor complex on DNA

Brain metabolism dictates the polarity of astrocyte control over arterioles

Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin

A fast, robust and tunable synthetic gene oscillator

The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm

Generation of cell polarity in plants links endocytosis, auxin distribution and cell fate decisions

Sarcolemma-localized nNOS is required to maintain activity after mild exercise

Transcription inactivation through local refolding of the RNA polymerase structure

Generation of a prostate from a single adult stem cell

Experience with moving visual stimuli drives the early development of cortical direction selectivity

53BP1 facilitates long-range DNA end-joining during V(D)J recombination

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

Sox18 induces development of the lymphatic vasculature in mice

Strong effect of dispersal network structure on ecological dynamics

The zinc-finger protein Zelda is a key activator of the early zygotic genome in Drosophila

Centrosome misorientation reduces stem cell division during ageing

The Phaeodactylum genome reveals the evolutionary history of diatom genomes

Direct control of paralysed muscles by cortical neurons

Entrained rhythmic activities of neuronal ensembles as perceptual memory of time interval

DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes

Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications

Generation of pluripotent stem cells from adult human testis

The ion pathway through the opened Na ,K -ATPase pump

Stereocilin-deficient mice reveal the origin of cochlear waveform distortions

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

Guarding the gateway to cortex with attention in visual thalamus

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1? production

The essential role of the CopN protein in Chlamydia pneumoniae intracellular growth

Oligopotent stem cells are distributed throughout the mammalian ocular surface

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs

The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers

Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks

The pectoral fin of Panderichthys and the origin of digits

Acoel development indicates the independent evolution of the bilaterian mouth and anus

Self-renewal and expansion of single transplanted muscle stem cells

Genes mirror geography within Europe

Structure of the guide-strand-containing argonaute silencing complex

Nature AOPNature AOPA role for VEGF as a negative regulator of pericyte function and vessel maturation

Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys

Role for perinuclear chromosome tethering in maintenance of genome stability

Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

WNT11 acts as a directional cue to organize the elongation of early muscle fibres

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

G protein G?i functions immediately downstream of Smoothened in Hedgehog signalling

HITS-CLIP yields genome-wide insights into brain alternative RNA processing

Alternative isoform regulation in human tissue transcriptomes

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex

Coordinate control of synaptic-layer specificity and rhodopsins in photoreceptor neurons

Temporal identity in axonal target layer recognition

Structure of the intact PPAR-?–RXR-? nuclear receptor complex on DNA

Brain metabolism dictates the polarity of astrocyte control over arterioles

Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin

A fast, robust and tunable synthetic gene oscillator

The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm

Generation of cell polarity in plants links endocytosis, auxin distribution and cell fate decisions

Sarcolemma-localized nNOS is required to maintain activity after mild exercise

Transcription inactivation through local refolding of the RNA polymerase structure

Generation of a prostate from a single adult stem cell

Experience with moving visual stimuli drives the early development of cortical direction selectivity

53BP1 facilitates long-range DNA end-joining during V(D)J recombination

53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

Sox18 induces development of the lymphatic vasculature in mice

Strong effect of dispersal network structure on ecological dynamics

The zinc-finger protein Zelda is a key activator of the early zygotic genome in Drosophila

Centrosome misorientation reduces stem cell division during ageing

The Phaeodactylum genome reveals the evolutionary history of diatom genomes

Direct control of paralysed muscles by cortical neurons

DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes

Generation of pluripotent stem cells from adult human testis

The ion pathway through the opened Na ,K -ATPase pump

Stereocilin-deficient mice reveal the origin of cochlear waveform distortions

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

Guarding the gateway to cortex with attention in visual thalamus

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1? production

Oligopotent stem cells are distributed throughout the mammalian ocular surface

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

The pectoral fin of Panderichthys and the origin of digits

Acoel development indicates the independent evolution of the bilaterian mouth and anus

Self-renewal and expansion of single transplanted muscle stem cells

Structure of the guide-strand-containing argonaute silencing complex

Nature AOPNature AOPThe dynein regulatory complex is required for ciliary motility and otolith biogenesis in the inner ear

Protein kinase R reveals an evolutionary model for defeating viral mimicry

Discovery of a sexual cycle in the opportunistic fungal pathogen Aspergillus fumigatus

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

A core gut microbiome in obese and lean twins

Major gradients in putatively nitrifying and non-nitrifying Archaea in the deep North Atlantic

Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology

Parallel adaptations to high temperatures in the Archaean eon

Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis

Ferritin is used for iron storage in bloom-forming marine pennate diatoms

Analysis of combinatorial cis-regulation in synthetic and genomic promoters

Dynamics of DNA replication loops reveal temporal control of lagging-strand synthesis

Pulsed contractions of an actin?myosin network drive apical constriction

Altered circadian rhythms regulate growth vigour in hybrids and allopolyploids

The replisome uses mRNA as a primer after colliding with RNA polymerase

Successful range-expanding plants experience less above-ground and below-ground enemy impact

Detecting influenza epidemics using search engine query data

Emergence of complex cell properties by learning to generalize in natural scenes

Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours

Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis

Low conservation of gene content in the Drosophila Y chromosome

Structural recognition and functional activation of Fc?R by innate pentraxins

Highly efficient molybdenum-based catalysts for enantioselective alkene metathesis

Experience leaves a lasting structural trace in cortical circuits

Regulation of ERBB2 by oestrogen receptor?PAX2 determines response to tamoxifen

Neural processing of auditory feedback during vocal practice in a songbird

Memory CD8 T-cell compartment grows in size with immunological experience

A role for VEGF as a negative regulator of pericyte function and vessel maturation

Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys

Role for perinuclear chromosome tethering in maintenance of genome stability

Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus

WNT11 acts as a directional cue to organize the elongation of early muscle fibres

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

G protein G?i functions immediately downstream of Smoothened in Hedgehog signalling

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex

Coordinate control of synaptic-layer specificity and rhodopsins in photoreceptor neurons

Temporal identity in axonal target layer recognition

Brain metabolism dictates the polarity of astrocyte control over arterioles

Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin

The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm

Generation of cell polarity in plants links endocytosis, auxin distribution and cell fate decisions

Transcription inactivation through local refolding of the RNA polymerase structure

Generation of a prostate from a single adult stem cell

Experience with moving visual stimuli drives the early development of cortical direction selectivity

Sox18 induces development of the lymphatic vasculature in mice

Strong effect of dispersal network structure on ecological dynamics

Centrosome misorientation reduces stem cell division during ageing

Direct control of paralysed muscles by cortical neurons

DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

The pectoral fin of Panderichthys and the origin of digits

Nature AOPNature AOPThe unfolded protein response signals through high-order assembly of Ire1

Messenger RNA targeting to endoplasmic reticulum stress signalling sites

RAD6?RAD18?RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light

Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans

Sleep and sensorimotor integration during early vocal learning in a songbird

Contact inhibition of locomotion in vivo controls neural crest directional migration

Endochondral ossification is required for haematopoietic stem-cell niche formation

Detoxification of sulphidic African shelf waters by blooming chemolithotrophs

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

Enhancing SIV-specific immunity in vivo by PD-1 blockade

Chlamydia causes fragmentation of the Golgi compartment to ensure reproduction

Endonucleolytic RNA cleavage by a eukaryotic exosome

ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development

Enterotoxigenic Escherichia coli EtpA mediates adhesion between flagella and host cells

Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

Counting RAD51 proteins disassembling from nucleoprotein filaments under tension

Spliceosomal cleavage generates the 3? end of telomerase RNA

Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche

Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival

A simple model of bipartite cooperation for ecological and organizational networks

Detection of functional haematopoietic stem cell niche using real-time imaging

The dynein regulatory complex is required for ciliary motility and otolith biogenesis in the inner ear

Protein kinase R reveals an evolutionary model for defeating viral mimicry

Discovery of a sexual cycle in the opportunistic fungal pathogen Aspergillus fumigatus

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

A core gut microbiome in obese and lean twins

Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology

Parallel adaptations to high temperatures in the Archaean eon

Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis

Ferritin is used for iron storage in bloom-forming marine pennate diatoms

Analysis of combinatorial cis-regulation in synthetic and genomic promoters

Dynamics of DNA replication loops reveal temporal control of lagging-strand synthesis

Pulsed contractions of an actin?myosin network drive apical constriction

Altered circadian rhythms regulate growth vigour in hybrids and allopolyploids

Successful range-expanding plants experience less above-ground and below-ground enemy impact

Detecting influenza epidemics using search engine query data

Emergence of complex cell properties by learning to generalize in natural scenes

Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours

Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis

Low conservation of gene content in the Drosophila Y chromosome

Structural recognition and functional activation of Fc?R by innate pentraxins

Highly efficient molybdenum-based catalysts for enantioselective alkene metathesis

Experience leaves a lasting structural trace in cortical circuits

Neural processing of auditory feedback during vocal practice in a songbird

Memory CD8 T-cell compartment grows in size with immunological experience

Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus

WNT11 acts as a directional cue to organize the elongation of early muscle fibres

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

G protein G?i functions immediately downstream of Smoothened in Hedgehog signalling

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex

The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm

Generation of cell polarity in plants links endocytosis, auxin distribution and cell fate decisions

Transcription inactivation through local refolding of the RNA polymerase structure

Experience with moving visual stimuli drives the early development of cortical direction selectivity

Nature AOPNature AOPInduced pluripotent stem cells from a spinal muscular atrophy patient

Direct observation of the nanoscale dynamics of membrane lipids in a living cell

Nodal signalling is involved in left?right asymmetry in snails

Artificial nanopores that mimic the transport selectivity of the nuclear pore complex

A stress-responsive RNA switch regulates VEGFA expression

WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity

Quality control by the ribosome following peptide bond formation

Crypt stem cells as the cells-of-origin of intestinal cancer

The DNA-encoded nucleosome organization of a eukaryotic genome

Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80

Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation

The unfolded protein response signals through high-order assembly of Ire1

Messenger RNA targeting to endoplasmic reticulum stress signalling sites

RAD6?RAD18?RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light

Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans

Sleep and sensorimotor integration during early vocal learning in a songbird

Endochondral ossification is required for haematopoietic stem-cell niche formation

Detoxification of sulphidic African shelf waters by blooming chemolithotrophs

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

Enhancing SIV-specific immunity in vivo by PD-1 blockade

Chlamydia causes fragmentation of the Golgi compartment to ensure reproduction

ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development

Enterotoxigenic Escherichia coli EtpA mediates adhesion between flagella and host cells

Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

Counting RAD51 proteins disassembling from nucleoprotein filaments under tension

Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche

Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival

A simple model of bipartite cooperation for ecological and organizational networks

Detection of functional haematopoietic stem cell niche using real-time imaging

The dynein regulatory complex is required for ciliary motility and otolith biogenesis in the inner ear

Protein kinase R reveals an evolutionary model for defeating viral mimicry

Discovery of a sexual cycle in the opportunistic fungal pathogen Aspergillus fumigatus

A core gut microbiome in obese and lean twins

Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis

Ferritin is used for iron storage in bloom-forming marine pennate diatoms

Analysis of combinatorial cis-regulation in synthetic and genomic promoters

Dynamics of DNA replication loops reveal temporal control of lagging-strand synthesis

Pulsed contractions of an actin?myosin network drive apical constriction

Altered circadian rhythms regulate growth vigour in hybrids and allopolyploids

Detecting influenza epidemics using search engine query data

Emergence of complex cell properties by learning to generalize in natural scenes

Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours

Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis

Experience leaves a lasting structural trace in cortical circuits

Neural processing of auditory feedback during vocal practice in a songbird

Memory CD8 T-cell compartment grows in size with immunological experience

Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

WNT11 acts as a directional cue to organize the elongation of early muscle fibres

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm

Transcription inactivation through local refolding of the RNA polymerase structure

Nature AOPNature AOPAdaptive immune features of natural killer cells

Transcriptome sequencing to detect gene fusions in cancer

Genetic architecture of mouse skin inflammation and tumour susceptibility

Intersubunit coordination in a homomeric ring ATPase

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

Ca2 /calmodulin regulates salicylic-acid-mediated plant immunity

Deficiency of a ?-arrestin-2 signal complex contributes to insulin resistance

Photon capture and signalling by melanopsin retinal ganglion cells

Casein kinase 1? governs antigen-receptor-induced NF-?B activation and human lymphoma cell survival

Pyrrolysyl-tRNA synthetase?tRNAPyl structure reveals the molecular basis of orthogonality

The Fas?FADD death domain complex structure unravels signalling by receptor clustering

Calcium flickers steer cell migration

Induced pluripotent stem cells from a spinal muscular atrophy patient

Direct observation of the nanoscale dynamics of membrane lipids in a living cell

Nodal signalling is involved in left?right asymmetry in snails

Artificial nanopores that mimic the transport selectivity of the nuclear pore complex

A stress-responsive RNA switch regulates VEGFA expression

Crypt stem cells as the cells-of-origin of intestinal cancer

The DNA-encoded nucleosome organization of a eukaryotic genome

Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80

Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation

The unfolded protein response signals through high-order assembly of Ire1

Messenger RNA targeting to endoplasmic reticulum stress signalling sites

RAD6?RAD18?RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light

Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans

Sleep and sensorimotor integration during early vocal learning in a songbird

Endochondral ossification is required for haematopoietic stem-cell niche formation

Detoxification of sulphidic African shelf waters by blooming chemolithotrophs

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

Enhancing SIV-specific immunity in vivo by PD-1 blockade

Chlamydia causes fragmentation of the Golgi compartment to ensure reproduction

ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development

Enterotoxigenic Escherichia coli EtpA mediates adhesion between flagella and host cells

Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

Counting RAD51 proteins disassembling from nucleoprotein filaments under tension

A simple model of bipartite cooperation for ecological and organizational networks

Protein kinase R reveals an evolutionary model for defeating viral mimicry

Discovery of a sexual cycle in the opportunistic fungal pathogen Aspergillus fumigatus

A core gut microbiome in obese and lean twins

Role for Spi-C in the development of red pulp macrophages and splenic iron homeostasis

Ferritin is used for iron storage in bloom-forming marine pennate diatoms

Dynamics of DNA replication loops reveal temporal control of lagging-strand synthesis

Pulsed contractions of an actin?myosin network drive apical constriction

Altered circadian rhythms regulate growth vigour in hybrids and allopolyploids

Detecting influenza epidemics using search engine query data

Experience leaves a lasting structural trace in cortical circuits

WNT11 acts as a directional cue to organize the elongation of early muscle fibres

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm

Transcription inactivation through local refolding of the RNA polymerase structure

Nature AOPNature AOPPost-transcriptional processing generates a diversity of 5?-modified long and short RNAs

Widespread bidirectional promoters are the major source of cryptic transcripts in yeast

Coenzyme recognition and gene regulation by a flavin mononucleotide riboswitch

Bidirectional promoters generate pervasive transcription in yeast

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

A high-mobility electron-transporting polymer for printed transistors

Cdc14 inhibits transcription by RNA polymerase I during anaphase

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

A micro-architecture for binocular disparity and ocular dominance in visual cortex

Intracortical circuits of pyramidal neurons reflect their long-range axonal targets

Dendritic encoding of sensory stimuli controlled by deep cortical interneurons

The subcellular organization of neocortical excitatory connections

Large-scale pattern growth of graphene films for stretchable transparent electrodes

Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA

Synaptic depression enables neuronal gain control

Adaptive immune features of natural killer cells

Transcriptome sequencing to detect gene fusions in cancer

Genetic architecture of mouse skin inflammation and tumour susceptibility

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

Ca2 /calmodulin regulates salicylic-acid-mediated plant immunity

Deficiency of a ?-arrestin-2 signal complex contributes to insulin resistance

Casein kinase 1? governs antigen-receptor-induced NF-?B activation and human lymphoma cell survival

Pyrrolysyl-tRNA synthetase?tRNAPyl structure reveals the molecular basis of orthogonality

The Fas?FADD death domain complex structure unravels signalling by receptor clustering

Calcium flickers steer cell migration

Direct observation of the nanoscale dynamics of membrane lipids in a living cell

Nodal signalling is involved in left?right asymmetry in snails

Artificial nanopores that mimic the transport selectivity of the nuclear pore complex

A stress-responsive RNA switch regulates VEGFA expression

Crypt stem cells as the cells-of-origin of intestinal cancer

The DNA-encoded nucleosome organization of a eukaryotic genome

Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80

Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation

The unfolded protein response signals through high-order assembly of Ire1

Messenger RNA targeting to endoplasmic reticulum stress signalling sites

RAD6?RAD18?RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light

Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans

Sleep and sensorimotor integration during early vocal learning in a songbird

Detoxification of sulphidic African shelf waters by blooming chemolithotrophs

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

Enhancing SIV-specific immunity in vivo by PD-1 blockade

Chlamydia causes fragmentation of the Golgi compartment to ensure reproduction

ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development

Enterotoxigenic Escherichia coli EtpA mediates adhesion between flagella and host cells

Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

Counting RAD51 proteins disassembling from nucleoprotein filaments under tension

Detecting influenza epidemics using search engine query data

WNT11 acts as a directional cue to organize the elongation of early muscle fibres

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

Nature AOPNature AOPAn unexpected twist in viral capsid maturation

Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis

Dynamic expression of epidermal caspase 8 simulates a wound healing response

Antiviral immunity in Drosophila requires systemic RNA interference spread

Specific synapses develop preferentially among sister excitatory neurons in the neocortex

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

Association of reactive oxygen species levels and radioresistance in cancer stem cells

Role of Jhdm2a in regulating metabolic gene expression and obesity resistance

Structure and function of the 5??3? exoribonuclease Rat1 and its activating partner Rai1

Crystal structure of an avian influenza polymerase PAN reveals an endonuclease active site

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

Transmembrane passage of hydrophobic compounds through a protein channel wall

A single regulatory gene is sufficient to alter bacterial host range

Phytoplankton in the ocean use non-phosphorus lipids in response to phosphorus scarcity

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses

The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage

Ionic high-pressure form of elemental boron

Human occludin is a hepatitis C virus entry factor required for infection of mouse cells

Organ regeneration does not require a functional stem cell niche in plants

Complete but curtailed T-cell response to very low-affinity antigen

Post-transcriptional processing generates a diversity of 5?-modified long and short RNAs

Widespread bidirectional promoters are the major source of cryptic transcripts in yeast

Coenzyme recognition and gene regulation by a flavin mononucleotide riboswitch

Bidirectional promoters generate pervasive transcription in yeast

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

Cdc14 inhibits transcription by RNA polymerase I during anaphase

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

A micro-architecture for binocular disparity and ocular dominance in visual cortex

Intracortical circuits of pyramidal neurons reflect their long-range axonal targets

Dendritic encoding of sensory stimuli controlled by deep cortical interneurons

The subcellular organization of neocortical excitatory connections

Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA

Synaptic depression enables neuronal gain control

Transcriptome sequencing to detect gene fusions in cancer

Genetic architecture of mouse skin inflammation and tumour susceptibility

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

Ca2 /calmodulin regulates salicylic-acid-mediated plant immunity

Deficiency of a ?-arrestin-2 signal complex contributes to insulin resistance

Casein kinase 1? governs antigen-receptor-induced NF-?B activation and human lymphoma cell survival

Pyrrolysyl-tRNA synthetase?tRNAPyl structure reveals the molecular basis of orthogonality

The Fas?FADD death domain complex structure unravels signalling by receptor clustering

Calcium flickers steer cell migration

Direct observation of the nanoscale dynamics of membrane lipids in a living cell

Nodal signalling is involved in left?right asymmetry in snails

Artificial nanopores that mimic the transport selectivity of the nuclear pore complex

A stress-responsive RNA switch regulates VEGFA expression

The DNA-encoded nucleosome organization of a eukaryotic genome

Sleep and sensorimotor integration during early vocal learning in a songbird

Enhancing SIV-specific immunity in vivo by PD-1 blockade

ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development

Detecting influenza epidemics using search engine query data

Nature AOPNature AOPTyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions

Membrane scission by the ESCRT-III complex

Inactivation of the Fto gene protects from obesity

Decoding reveals the contents of visual working memory in early visual areas

Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates

Phylogenetic biome conservatism on a global scale

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

Identification of a dendritic cell receptor that couples sensing of necrosis to immunity

IFN? activates dormant haematopoietic stem cells in vivo

Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells

Population genomics of domestic and wild yeasts

Comprehensive polymorphism survey elucidates population structure of Saccharomyces cerevisiae

An unexpected twist in viral capsid maturation

Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis

Dynamic expression of epidermal caspase 8 simulates a wound healing response

Antiviral immunity in Drosophila requires systemic RNA interference spread

Specific synapses develop preferentially among sister excitatory neurons in the neocortex

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

Association of reactive oxygen species levels and radioresistance in cancer stem cells

Role of Jhdm2a in regulating metabolic gene expression and obesity resistance

Structure and function of the 5??3? exoribonuclease Rat1 and its activating partner Rai1

Crystal structure of an avian influenza polymerase PAN reveals an endonuclease active site

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

Transmembrane passage of hydrophobic compounds through a protein channel wall

A single regulatory gene is sufficient to alter bacterial host range

Phytoplankton in the ocean use non-phosphorus lipids in response to phosphorus scarcity

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses

Organ regeneration does not require a functional stem cell niche in plants

Complete but curtailed T-cell response to very low-affinity antigen

Coenzyme recognition and gene regulation by a flavin mononucleotide riboswitch

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

Cdc14 inhibits transcription by RNA polymerase I during anaphase

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

A micro-architecture for binocular disparity and ocular dominance in visual cortex

Intracortical circuits of pyramidal neurons reflect their long-range axonal targets

Dendritic encoding of sensory stimuli controlled by deep cortical interneurons

The subcellular organization of neocortical excitatory connections

Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA

Transcriptome sequencing to detect gene fusions in cancer

Genetic architecture of mouse skin inflammation and tumour susceptibility

Ca2 /calmodulin regulates salicylic-acid-mediated plant immunity

Deficiency of a ?-arrestin-2 signal complex contributes to insulin resistance

Casein kinase 1? governs antigen-receptor-induced NF-?B activation and human lymphoma cell survival

Pyrrolysyl-tRNA synthetase?tRNAPyl structure reveals the molecular basis of orthogonality

Direct observation of the nanoscale dynamics of membrane lipids in a living cell

The DNA-encoded nucleosome organization of a eukaryotic genome

Sleep and sensorimotor integration during early vocal learning in a songbird

Enhancing SIV-specific immunity in vivo by PD-1 blockade

Nature AOPNature AOPCBP/p300-mediated acetylation of histone H3 on lysine 56

Electromotive force and huge magnetoresistance in magnetic tunnel junctions

Decision-related activity in sensory neurons reflects more than a neuron?s causal effect

Initial community evenness favours functionality under selective stress

Embryonic stem cells use ZFP809 to silence retroviral DNAs

AMPK regulates energy expenditure by modulating NAD metabolism and SIRT1 activity

Glycerol monolaurate prevents mucosal SIV transmission

Natural variation in a neural globin tunes oxygen sensing in wild Caenorhabditis elegans

Germline-encoded amino acids in the ?? T-cell receptor control thymic selection

A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range

Virus-free induction of pluripotency and subsequent excision of reprogramming factors

Toxin B is essential for virulence of Clostridium difficile

The structural basis of lipopolysaccharide recognition by the TLR4?MD-2 complex

piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells

Nicotine binding to brain receptors requires a strong cation?? interaction

Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease

Adaptation of HIV-1 to human leukocyte antigen class I

FGF signalling during embryo development regulates cilia length in diverse epithelia

Clustering of InsP3 receptors by InsP3 retunes their regulation by InsP3 and Ca2

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions

Membrane scission by the ESCRT-III complex

Inactivation of the Fto gene protects from obesity

Decoding reveals the contents of visual working memory in early visual areas

Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates

Phylogenetic biome conservatism on a global scale

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

Identification of a dendritic cell receptor that couples sensing of necrosis to immunity

IFN? activates dormant haematopoietic stem cells in vivo

Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells

Population genomics of domestic and wild yeasts

Comprehensive polymorphism survey elucidates population structure of Saccharomyces cerevisiae

An unexpected twist in viral capsid maturation

Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis

Dynamic expression of epidermal caspase 8 simulates a wound healing response

Antiviral immunity in Drosophila requires systemic RNA interference spread

Specific synapses develop preferentially among sister excitatory neurons in the neocortex

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

Association of reactive oxygen species levels and radioresistance in cancer stem cells

Role of Jhdm2a in regulating metabolic gene expression and obesity resistance

Structure and function of the 5??3? exoribonuclease Rat1 and its activating partner Rai1

Crystal structure of an avian influenza polymerase PAN reveals an endonuclease active site

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

Transmembrane passage of hydrophobic compounds through a protein channel wall

A single regulatory gene is sufficient to alter bacterial host range

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses

Complete but curtailed T-cell response to very low-affinity antigen

Coenzyme recognition and gene regulation by a flavin mononucleotide riboswitch

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

Cdc14 inhibits transcription by RNA polymerase I during anaphase

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

A micro-architecture for binocular disparity and ocular dominance in visual cortex

Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA

Genetic architecture of mouse skin inflammation and tumour susceptibility

The DNA-encoded nucleosome organization of a eukaryotic genome

Enhancing SIV-specific immunity in vivo by PD-1 blockade

Nature AOPNature AOPA massive hypergiant star as the progenitor of the supernova SN 2005gl

Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis

Temporally precise in vivo control of intracellular signalling

Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division

Histone modifications at human enhancers reflect global cell-type-specific gene expression

Gene regulatory logic of dopamine neuron differentiation

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

Tumours with PI3K activation are resistant to dietary restriction

Compound vesicle fusion increases quantal size and potentiates synaptic transmission

CBP/p300-mediated acetylation of histone H3 on lysine 56

Electromotive force and huge magnetoresistance in magnetic tunnel junctions

Decision-related activity in sensory neurons reflects more than a neuron?s causal effect

Initial community evenness favours functionality under selective stress

Embryonic stem cells use ZFP809 to silence retroviral DNAs

AMPK regulates energy expenditure by modulating NAD metabolism and SIRT1 activity

Glycerol monolaurate prevents mucosal SIV transmission

Natural variation in a neural globin tunes oxygen sensing in wild Caenorhabditis elegans

Germline-encoded amino acids in the ?? T-cell receptor control thymic selection

A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range

Virus-free induction of pluripotency and subsequent excision of reprogramming factors

Toxin B is essential for virulence of Clostridium difficile

The structural basis of lipopolysaccharide recognition by the TLR4?MD-2 complex

piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells

Nicotine binding to brain receptors requires a strong cation?? interaction

Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease

Adaptation of HIV-1 to human leukocyte antigen class I

FGF signalling during embryo development regulates cilia length in diverse epithelia

Clustering of InsP3 receptors by InsP3 retunes their regulation by InsP3 and Ca2

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions

Inactivation of the Fto gene protects from obesity

Decoding reveals the contents of visual working memory in early visual areas

Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates

Phylogenetic biome conservatism on a global scale

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

Identification of a dendritic cell receptor that couples sensing of necrosis to immunity

IFN? activates dormant haematopoietic stem cells in vivo

Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells

An unexpected twist in viral capsid maturation

Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis

Dynamic expression of epidermal caspase 8 simulates a wound healing response

Specific synapses develop preferentially among sister excitatory neurons in the neocortex

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

Association of reactive oxygen species levels and radioresistance in cancer stem cells

Role of Jhdm2a in regulating metabolic gene expression and obesity resistance

Structure and function of the 5??3? exoribonuclease Rat1 and its activating partner Rai1

Crystal structure of an avian influenza polymerase PAN reveals an endonuclease active site

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

A micro-architecture for binocular disparity and ocular dominance in visual cortex

Genetic architecture of mouse skin inflammation and tumour susceptibility

Nature AOPNature AOPSnowdrift game dynamics and facultative cheating in yeast

A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans

Genetic analysis of radiation-induced changes in human gene expression

Structural basis for leucine-rich nuclear export signal recognition by CRM1

Autophagy regulates lipid metabolism

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

Evolutionary diversification in stickleback affects ecosystem functioning

Detection and trapping of intermediate states priming nicotinic receptor channel opening

Two-year-olds with autism orient to non-social contingencies rather than biological motion

Single Lgr5 stem cells build crypt–villus structures in vitro without a mesenchymal niche

Haematopoietic stem cells depend on G?s-mediated signalling to engraft bone marrow

Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay

A massive hypergiant star as the progenitor of the supernova SN 2005gl

Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis

Temporally precise in vivo control of intracellular signalling

Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division

Histone modifications at human enhancers reflect global cell-type-specific gene expression

Gene regulatory logic of dopamine neuron differentiation

Tumours with PI3K activation are resistant to dietary restriction

Compound vesicle fusion increases quantal size and potentiates synaptic transmission

CBP/p300-mediated acetylation of histone H3 on lysine 56

Decision-related activity in sensory neurons reflects more than a neuron?s causal effect

Embryonic stem cells use ZFP809 to silence retroviral DNAs

AMPK regulates energy expenditure by modulating NAD metabolism and SIRT1 activity

Glycerol monolaurate prevents mucosal SIV transmission

Natural variation in a neural globin tunes oxygen sensing in wild Caenorhabditis elegans

Germline-encoded amino acids in the ?? T-cell receptor control thymic selection

A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range

Virus-free induction of pluripotency and subsequent excision of reprogramming factors

Toxin B is essential for virulence of Clostridium difficile

The structural basis of lipopolysaccharide recognition by the TLR4?MD-2 complex

piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells

Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease

Inactivation of the Fto gene protects from obesity

Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates

Phylogenetic biome conservatism on a global scale

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

Identification of a dendritic cell receptor that couples sensing of necrosis to immunity

IFN? activates dormant haematopoietic stem cells in vivo

The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

Association of reactive oxygen species levels and radioresistance in cancer stem cells

Role of Jhdm2a in regulating metabolic gene expression and obesity resistance

Structure and function of the 5??3? exoribonuclease Rat1 and its activating partner Rai1

Crystal structure of an avian influenza polymerase PAN reveals an endonuclease active site

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

Nature AOPNature AOPGlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis

A yeast-endonuclease-generated DNA break induces antigenic switching in Trypanosoma brucei

PEP1 regulates perennial flowering in Arabis alpina

Genome-wide analysis of Notch signalling in Drosophila by transgenic RNAi

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

Discovery of dual function acridones as a new antimalarial chemotype

CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle

Snowdrift game dynamics and facultative cheating in yeast

A hub-and-spoke circuit drives pheromone attraction and social behaviour in C. elegans

Genetic analysis of radiation-induced changes in human gene expression

Structural basis for leucine-rich nuclear export signal recognition by CRM1

Autophagy regulates lipid metabolism

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

Evolutionary diversification in stickleback affects ecosystem functioning

Detection and trapping of intermediate states priming nicotinic receptor channel opening

Two-year-olds with autism orient to non-social contingencies rather than biological motion

Single Lgr5 stem cells build crypt–villus structures in vitro without a mesenchymal niche

Haematopoietic stem cells depend on G?s-mediated signalling to engraft bone marrow

Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay

Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis

Temporally precise in vivo control of intracellular signalling

Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division

Histone modifications at human enhancers reflect global cell-type-specific gene expression

Compound vesicle fusion increases quantal size and potentiates synaptic transmission

CBP/p300-mediated acetylation of histone H3 on lysine 56

Decision-related activity in sensory neurons reflects more than a neuron?s causal effect

Embryonic stem cells use ZFP809 to silence retroviral DNAs

AMPK regulates energy expenditure by modulating NAD metabolism and SIRT1 activity

Glycerol monolaurate prevents mucosal SIV transmission

Natural variation in a neural globin tunes oxygen sensing in wild Caenorhabditis elegans

Germline-encoded amino acids in the ?? T-cell receptor control thymic selection

A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range

Toxin B is essential for virulence of Clostridium difficile

The structural basis of lipopolysaccharide recognition by the TLR4?MD-2 complex

Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease

Nature AOPNature AOPMutations of multiple genes cause deregulation of NF-?B in diffuse large B-cell lymphoma

De novo establishment of wild-type song culture in the zebra finch

Frequent inactivation of A20 in B-cell lymphomas

F-box protein FBXO31 mediates cyclin D1 degradation to induce G1 arrest after DNA damage

Bmi1 regulates mitochondrial function and the DNA damage response pathway

Mechanism of differential control of NMDA receptor activity by NR2 subunits

Precise genome modification in the crop species Zea mays using zinc-finger nucleases

High-frequency modification of plant genes using engineered zinc-finger nucleases

Common genetic variants on 5p14.1 associate with autism spectrum disorders

Autism genome-wide copy number variation reveals ubiquitin and neuronal genes