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 Nature GeneticsNature GeneticsWhat is the Human Variome Project?
A database of locus-specific databases
PharmGKB: a logical home for knowledge relating genotype to drug response phenotype
Analysis of published PKD1 gene sequence variants
Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency
Nature GeneticsNature GeneticsWhat is the Human Variome Project?
A database of locus-specific databases
PharmGKB: a logical home for knowledge relating genotype to drug response phenotype
Analysis of published PKD1 gene sequence variants
Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency
Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency
Recommendations of the 2006 Human Variome Project meeting
The way we were?
The resequencing imperative
How missing genes interact
The human promoter methylome
Drosophila melanogaster neurofibromatosis-1: ROS, not Ras?
Mitochondrial DNA mutations and aging: a case closed?
Touching base
Research highlights
A recurrent mutation in MED12 leading to R961W causes Opitz-Kaveggia syndrome
Homozygous silencing of T-box transcription factor EOMES leads to microcephaly with polymicrogyria and corpus callosum agenesis
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
SMAD4-deficient intestinal tumors recruit CCR1 myeloid cells that promote invasion
Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster
The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast
Genetic basis of individual differences in the response to small-molecule drugs in yeast
A module of negative feedback regulators defines growth factor signaling
Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL
Stepwise replication identifies a low-producing lymphotoxin-? allele as a major risk factor for early-onset leprosy
A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis
A functional polymorphism in the 5? UTR of GDF5 is associated with susceptibility to osteoarthritis
Mitochondrial aspartyl-tRNA synthetase deficiency causes leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation
Mitochondrial point mutations do not limit the natural lifespan of mice
The heterochronic maize mutant Corngrass1 results from overexpression of a tandem microRNA
Epistatic buffering of fitness loss in yeast double deletion strains
Distributions of epistasis in microbes fit predictions from a fitness landscape model
Genome-wide functional analysis of pathogenicity genes in the rice blast fungus
Corrigendum: High-throughput oncogene mutation profiling in human cancer
Corrigendum: Cross-talk and decision making in MAP kinase pathways
Corrigendum: A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration
Corrigendum: Genome variation and evolution of the malaria parasite Plasmodium falciparum
Nature GeneticsNature GeneticsWhat is the Human Variome Project?
A database of locus-specific databases
PharmGKB: a logical home for knowledge relating genotype to drug response phenotype
Analysis of published PKD1 gene sequence variants
Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency
Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency
Recommendations of the 2006 Human Variome Project meeting
The way we were?
The resequencing imperative
How missing genes interact
The human promoter methylome
Drosophila melanogaster neurofibromatosis-1: ROS, not Ras?
Mitochondrial DNA mutations and aging: a case closed?
Touching base
Research highlights
A recurrent mutation in MED12 leading to R961W causes Opitz-Kaveggia syndrome
Homozygous silencing of T-box transcription factor EOMES leads to microcephaly with polymicrogyria and corpus callosum agenesis
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
SMAD4-deficient intestinal tumors recruit CCR1 myeloid cells that promote invasion
Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster
The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast
Genetic basis of individual differences in the response to small-molecule drugs in yeast
A module of negative feedback regulators defines growth factor signaling
Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL
Stepwise replication identifies a low-producing lymphotoxin-? allele as a major risk factor for early-onset leprosy
A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis
A functional polymorphism in the 5? UTR of GDF5 is associated with susceptibility to osteoarthritis
Mitochondrial aspartyl-tRNA synthetase deficiency causes leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation
Mitochondrial point mutations do not limit the natural lifespan of mice
The heterochronic maize mutant Corngrass1 results from overexpression of a tandem microRNA
Epistatic buffering of fitness loss in yeast double deletion strains
Distributions of epistasis in microbes fit predictions from a fitness landscape model
Genome-wide functional analysis of pathogenicity genes in the rice blast fungus
Corrigendum: High-throughput oncogene mutation profiling in human cancer
Corrigendum: Cross-talk and decision making in MAP kinase pathways
Corrigendum: A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration
Corrigendum: Genome variation and evolution of the malaria parasite Plasmodium falciparum
Nature GeneticsNature GeneticsWhat is the Human Variome Project?
A database of locus-specific databases
PharmGKB: a logical home for knowledge relating genotype to drug response phenotype
Analysis of published PKD1 gene sequence variants
Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency
Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency
Recommendations of the 2006 Human Variome Project meeting
The way we were?
The resequencing imperative
How missing genes interact
The human promoter methylome
Drosophila melanogaster neurofibromatosis-1: ROS, not Ras?
Mitochondrial DNA mutations and aging: a case closed?
Touching base
Research highlights
A recurrent mutation in MED12 leading to R961W causes Opitz-Kaveggia syndrome
Homozygous silencing of T-box transcription factor EOMES leads to microcephaly with polymicrogyria and corpus callosum agenesis
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
SMAD4-deficient intestinal tumors recruit CCR1 myeloid cells that promote invasion
Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster
The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast
Genetic basis of individual differences in the response to small-molecule drugs in yeast
A module of negative feedback regulators defines growth factor signaling
Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL
Stepwise replication identifies a low-producing lymphotoxin-? allele as a major risk factor for early-onset leprosy
A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis
A functional polymorphism in the 5? UTR of GDF5 is associated with susceptibility to osteoarthritis
Mitochondrial aspartyl-tRNA synthetase deficiency causes leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation
Mitochondrial point mutations do not limit the natural lifespan of mice
The heterochronic maize mutant Corngrass1 results from overexpression of a tandem microRNA
Epistatic buffering of fitness loss in yeast double deletion strains
Distributions of epistasis in microbes fit predictions from a fitness landscape model
Genome-wide functional analysis of pathogenicity genes in the rice blast fungus
Corrigendum: High-throughput oncogene mutation profiling in human cancer
Corrigendum: Cross-talk and decision making in MAP kinase pathways
Corrigendum: A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration
Corrigendum: Genome variation and evolution of the malaria parasite Plasmodium falciparum
Nature GeneticsNature GeneticsWhat is the Human Variome Project?
A database of locus-specific databases
PharmGKB: a logical home for knowledge relating genotype to drug response phenotype
Analysis of published PKD1 gene sequence variants
Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency
Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency
Recommendations of the 2006 Human Variome Project meeting
The way we were?
The resequencing imperative
How missing genes interact
The human promoter methylome
Drosophila melanogaster neurofibromatosis-1: ROS, not Ras?
Mitochondrial DNA mutations and aging: a case closed?
Touching base
Research highlights
A recurrent mutation in MED12 leading to R961W causes Opitz-Kaveggia syndrome
Homozygous silencing of T-box transcription factor EOMES leads to microcephaly with polymicrogyria and corpus callosum agenesis
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
SMAD4-deficient intestinal tumors recruit CCR1 myeloid cells that promote invasion
Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster
The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast
Genetic basis of individual differences in the response to small-molecule drugs in yeast
A module of negative feedback regulators defines growth factor signaling
Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL
Stepwise replication identifies a low-producing lymphotoxin-? allele as a major risk factor for early-onset leprosy
A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis
A functional polymorphism in the 5? UTR of GDF5 is associated with susceptibility to osteoarthritis
Mitochondrial aspartyl-tRNA synthetase deficiency causes leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation
Mitochondrial point mutations do not limit the natural lifespan of mice
The heterochronic maize mutant Corngrass1 results from overexpression of a tandem microRNA
Epistatic buffering of fitness loss in yeast double deletion strains
Distributions of epistasis in microbes fit predictions from a fitness landscape model
Genome-wide functional analysis of pathogenicity genes in the rice blast fungus
Corrigendum: High-throughput oncogene mutation profiling in human cancer
Corrigendum: Cross-talk and decision making in MAP kinase pathways
Corrigendum: A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration
Corrigendum: Genome variation and evolution of the malaria parasite Plasmodium falciparum
Nature GeneticsNature GeneticsGenomics of common diseases
Reactive oxygen species and the segregation of mtDNA sequence variants
Reply to ?Reactive oxygen species and the segregation of mtDNA sequence variants?
Inherited epimutation or a haplotypic basis for the propensity to silence?
Heritable germline epimutations in humans
Heritable germline epimutation is not the same as transgenerational epigenetic inheritance
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Nature GeneticsNature GeneticsGenomics of common diseases
Reactive oxygen species and the segregation of mtDNA sequence variants
Reply to ?Reactive oxygen species and the segregation of mtDNA sequence variants?
Inherited epimutation or a haplotypic basis for the propensity to silence?
Heritable germline epimutations in humans
Heritable germline epimutation is not the same as transgenerational epigenetic inheritance
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Genes get diabolical
Multiple prostate cancer risk variants on 8q24
Road rage and fruit flies
MicroRNAs as tumor suppressors
A quantitative trait locus regulating rice grain width
Touching base
Research highlights
Drosophila researchers focus on human disease
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers
Modifiers of epigenetic reprogramming show paternal effects in the mouse
A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
Multiple regions within 8q24 independently affect risk for prostate cancer
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema
Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer
Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility
Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models
Impaired microRNA processing enhances cellular transformation and tumorigenesis
Serotonin and neuropeptide F have opposite modulatory effects on fly aggression
Genetic reconstruction of a functional transcriptional regulatory network
Corrigendum: Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species
Corrigendum: A common coding variant in CASP8 is associated with breast cancer risk
Nature GeneticsNature GeneticsGenomics of common diseases
Reactive oxygen species and the segregation of mtDNA sequence variants
Reply to ?Reactive oxygen species and the segregation of mtDNA sequence variants?
Inherited epimutation or a haplotypic basis for the propensity to silence?
Heritable germline epimutations in humans
Heritable germline epimutation is not the same as transgenerational epigenetic inheritance
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Genes get diabolical
Multiple prostate cancer risk variants on 8q24
Road rage and fruit flies
MicroRNAs as tumor suppressors
A quantitative trait locus regulating rice grain width
Touching base
Research highlights
Drosophila researchers focus on human disease
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers
Modifiers of epigenetic reprogramming show paternal effects in the mouse
A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
Multiple regions within 8q24 independently affect risk for prostate cancer
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema
Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer
Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility
Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models
Impaired microRNA processing enhances cellular transformation and tumorigenesis
Serotonin and neuropeptide F have opposite modulatory effects on fly aggression
Genetic reconstruction of a functional transcriptional regulatory network
Corrigendum: Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species
Corrigendum: A common coding variant in CASP8 is associated with breast cancer risk
Nature GeneticsNature GeneticsGenomics of common diseases
Reactive oxygen species and the segregation of mtDNA sequence variants
Reply to ?Reactive oxygen species and the segregation of mtDNA sequence variants?
Inherited epimutation or a haplotypic basis for the propensity to silence?
Heritable germline epimutations in humans
Heritable germline epimutation is not the same as transgenerational epigenetic inheritance
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Genes get diabolical
Multiple prostate cancer risk variants on 8q24
Road rage and fruit flies
MicroRNAs as tumor suppressors
A quantitative trait locus regulating rice grain width
Touching base
Research highlights
Drosophila researchers focus on human disease
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers
Modifiers of epigenetic reprogramming show paternal effects in the mouse
A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
Multiple regions within 8q24 independently affect risk for prostate cancer
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema
Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer
Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility
Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models
Impaired microRNA processing enhances cellular transformation and tumorigenesis
Serotonin and neuropeptide F have opposite modulatory effects on fly aggression
Genetic reconstruction of a functional transcriptional regulatory network
Corrigendum: Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species
Corrigendum: A common coding variant in CASP8 is associated with breast cancer risk
Nature GeneticsNature GeneticsGenomics of common diseases
Reactive oxygen species and the segregation of mtDNA sequence variants
Reply to ?Reactive oxygen species and the segregation of mtDNA sequence variants?
Inherited epimutation or a haplotypic basis for the propensity to silence?
Heritable germline epimutations in humans
Heritable germline epimutation is not the same as transgenerational epigenetic inheritance
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Genes get diabolical
Multiple prostate cancer risk variants on 8q24
Road rage and fruit flies
MicroRNAs as tumor suppressors
A quantitative trait locus regulating rice grain width
Touching base
Research highlights
Drosophila researchers focus on human disease
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers
Modifiers of epigenetic reprogramming show paternal effects in the mouse
A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
Multiple regions within 8q24 independently affect risk for prostate cancer
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema
Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer
Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility
Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models
Impaired microRNA processing enhances cellular transformation and tumorigenesis
Serotonin and neuropeptide F have opposite modulatory effects on fly aggression
Genetic reconstruction of a functional transcriptional regulatory network
Corrigendum: Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species
Corrigendum: A common coding variant in CASP8 is associated with breast cancer risk
Nature GeneticsNature GeneticsGenomics of common diseases
Reactive oxygen species and the segregation of mtDNA sequence variants
Reply to ?Reactive oxygen species and the segregation of mtDNA sequence variants?
Inherited epimutation or a haplotypic basis for the propensity to silence?
Heritable germline epimutations in humans
Heritable germline epimutation is not the same as transgenerational epigenetic inheritance
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Genes get diabolical
Multiple prostate cancer risk variants on 8q24
Road rage and fruit flies
MicroRNAs as tumor suppressors
A quantitative trait locus regulating rice grain width
Touching base
Research highlights
Drosophila researchers focus on human disease
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers
Modifiers of epigenetic reprogramming show paternal effects in the mouse
A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
Multiple regions within 8q24 independently affect risk for prostate cancer
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema
Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer
Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility
Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models
Impaired microRNA processing enhances cellular transformation and tumorigenesis
Serotonin and neuropeptide F have opposite modulatory effects on fly aggression
Genetic reconstruction of a functional transcriptional regulatory network
Corrigendum: Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species
Corrigendum: A common coding variant in CASP8 is associated with breast cancer risk
Nature GeneticsNature GeneticsGenomics of common diseases
Reactive oxygen species and the segregation of mtDNA sequence variants
Reply to ?Reactive oxygen species and the segregation of mtDNA sequence variants?
Inherited epimutation or a haplotypic basis for the propensity to silence?
Heritable germline epimutations in humans
Heritable germline epimutation is not the same as transgenerational epigenetic inheritance
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Genes get diabolical
Multiple prostate cancer risk variants on 8q24
Road rage and fruit flies
MicroRNAs as tumor suppressors
A quantitative trait locus regulating rice grain width
Touching base
Research highlights
Drosophila researchers focus on human disease
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers
Modifiers of epigenetic reprogramming show paternal effects in the mouse
A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
Multiple regions within 8q24 independently affect risk for prostate cancer
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema
Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer
Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility
Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models
Impaired microRNA processing enhances cellular transformation and tumorigenesis
Serotonin and neuropeptide F have opposite modulatory effects on fly aggression
Genetic reconstruction of a functional transcriptional regulatory network
Corrigendum: Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species
Corrigendum: A common coding variant in CASP8 is associated with breast cancer risk
Nature GeneticsNature GeneticsGenomics of common diseases
Reactive oxygen species and the segregation of mtDNA sequence variants
Reply to ?Reactive oxygen species and the segregation of mtDNA sequence variants?
Inherited epimutation or a haplotypic basis for the propensity to silence?
Heritable germline epimutations in humans
Heritable germline epimutation is not the same as transgenerational epigenetic inheritance
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Genes get diabolical
Multiple prostate cancer risk variants on 8q24
Road rage and fruit flies
MicroRNAs as tumor suppressors
A quantitative trait locus regulating rice grain width
Touching base
Research highlights
Drosophila researchers focus on human disease
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers
Modifiers of epigenetic reprogramming show paternal effects in the mouse
A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
Multiple regions within 8q24 independently affect risk for prostate cancer
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema
Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer
Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility
Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models
Impaired microRNA processing enhances cellular transformation and tumorigenesis
Serotonin and neuropeptide F have opposite modulatory effects on fly aggression
Genetic reconstruction of a functional transcriptional regulatory network
Corrigendum: Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species
Corrigendum: A common coding variant in CASP8 is associated with breast cancer risk
Nature GeneticsNature GeneticsGenomics of common diseases
Reactive oxygen species and the segregation of mtDNA sequence variants
Reply to ?Reactive oxygen species and the segregation of mtDNA sequence variants?
Inherited epimutation or a haplotypic basis for the propensity to silence?
Heritable germline epimutations in humans
Heritable germline epimutation is not the same as transgenerational epigenetic inheritance
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Genes get diabolical
Multiple prostate cancer risk variants on 8q24
Road rage and fruit flies
MicroRNAs as tumor suppressors
A quantitative trait locus regulating rice grain width
Touching base
Research highlights
Drosophila researchers focus on human disease
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers
Modifiers of epigenetic reprogramming show paternal effects in the mouse
A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
Multiple regions within 8q24 independently affect risk for prostate cancer
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema
Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer
Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility
Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models
Impaired microRNA processing enhances cellular transformation and tumorigenesis
Serotonin and neuropeptide F have opposite modulatory effects on fly aggression
Genetic reconstruction of a functional transcriptional regulatory network
Corrigendum: Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species
Corrigendum: A common coding variant in CASP8 is associated with breast cancer risk
Nature GeneticsNature GeneticsGenomics of common diseases
Reactive oxygen species and the segregation of mtDNA sequence variants
Reply to ?Reactive oxygen species and the segregation of mtDNA sequence variants?
Inherited epimutation or a haplotypic basis for the propensity to silence?
Heritable germline epimutations in humans
Heritable germline epimutation is not the same as transgenerational epigenetic inheritance
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Genes get diabolical
Multiple prostate cancer risk variants on 8q24
Road rage and fruit flies
MicroRNAs as tumor suppressors
A quantitative trait locus regulating rice grain width
Touching base
Research highlights
Drosophila researchers focus on human disease
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers
Modifiers of epigenetic reprogramming show paternal effects in the mouse
A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
Multiple regions within 8q24 independently affect risk for prostate cancer
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema
Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer
Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility
Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models
Impaired microRNA processing enhances cellular transformation and tumorigenesis
Serotonin and neuropeptide F have opposite modulatory effects on fly aggression
Genetic reconstruction of a functional transcriptional regulatory network
Corrigendum: Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species
Corrigendum: A common coding variant in CASP8 is associated with breast cancer risk
Nature GeneticsNature GeneticsGenomics of common diseases
Reactive oxygen species and the segregation of mtDNA sequence variants
Reply to ?Reactive oxygen species and the segregation of mtDNA sequence variants?
Inherited epimutation or a haplotypic basis for the propensity to silence?
Heritable germline epimutations in humans
Heritable germline epimutation is not the same as transgenerational epigenetic inheritance
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Genes get diabolical
Multiple prostate cancer risk variants on 8q24
Road rage and fruit flies
MicroRNAs as tumor suppressors
A quantitative trait locus regulating rice grain width
Touching base
Research highlights
Drosophila researchers focus on human disease
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers
Modifiers of epigenetic reprogramming show paternal effects in the mouse
A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
Multiple regions within 8q24 independently affect risk for prostate cancer
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema
Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer
Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility
Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models
Impaired microRNA processing enhances cellular transformation and tumorigenesis
Serotonin and neuropeptide F have opposite modulatory effects on fly aggression
Genetic reconstruction of a functional transcriptional regulatory network
Corrigendum: Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species
Corrigendum: A common coding variant in CASP8 is associated with breast cancer risk
Nature GeneticsNature GeneticsGenomics of common diseases
Reactive oxygen species and the segregation of mtDNA sequence variants
Reply to ?Reactive oxygen species and the segregation of mtDNA sequence variants?
Inherited epimutation or a haplotypic basis for the propensity to silence?
Heritable germline epimutations in humans
Heritable germline epimutation is not the same as transgenerational epigenetic inheritance
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Genes get diabolical
Multiple prostate cancer risk variants on 8q24
Road rage and fruit flies
MicroRNAs as tumor suppressors
A quantitative trait locus regulating rice grain width
Touching base
Research highlights
Drosophila researchers focus on human disease
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers
Modifiers of epigenetic reprogramming show paternal effects in the mouse
A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
Multiple regions within 8q24 independently affect risk for prostate cancer
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema
Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer
Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility
Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models
Impaired microRNA processing enhances cellular transformation and tumorigenesis
Serotonin and neuropeptide F have opposite modulatory effects on fly aggression
Genetic reconstruction of a functional transcriptional regulatory network
Corrigendum: Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species
Corrigendum: A common coding variant in CASP8 is associated with breast cancer risk
Nature GeneticsNature GeneticsGenomics of common diseases
Reactive oxygen species and the segregation of mtDNA sequence variants
Reply to ?Reactive oxygen species and the segregation of mtDNA sequence variants?
Inherited epimutation or a haplotypic basis for the propensity to silence?
Heritable germline epimutations in humans
Heritable germline epimutation is not the same as transgenerational epigenetic inheritance
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Genes get diabolical
Multiple prostate cancer risk variants on 8q24
Road rage and fruit flies
MicroRNAs as tumor suppressors
A quantitative trait locus regulating rice grain width
Touching base
Research highlights
Drosophila researchers focus on human disease
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers
Modifiers of epigenetic reprogramming show paternal effects in the mouse
A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
Multiple regions within 8q24 independently affect risk for prostate cancer
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema
Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer
Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility
Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models
Impaired microRNA processing enhances cellular transformation and tumorigenesis
Serotonin and neuropeptide F have opposite modulatory effects on fly aggression
Genetic reconstruction of a functional transcriptional regulatory network
Corrigendum: Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species
Corrigendum: A common coding variant in CASP8 is associated with breast cancer risk
Nature GeneticsNature GeneticsGenomics of common diseases
Reactive oxygen species and the segregation of mtDNA sequence variants
Reply to ?Reactive oxygen species and the segregation of mtDNA sequence variants?
Inherited epimutation or a haplotypic basis for the propensity to silence?
Heritable germline epimutations in humans
Heritable germline epimutation is not the same as transgenerational epigenetic inheritance
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Genes get diabolical
Multiple prostate cancer risk variants on 8q24
Road rage and fruit flies
MicroRNAs as tumor suppressors
A quantitative trait locus regulating rice grain width
Touching base
Research highlights
Drosophila researchers focus on human disease
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers
Modifiers of epigenetic reprogramming show paternal effects in the mouse
A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
Multiple regions within 8q24 independently affect risk for prostate cancer
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema
Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer
Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility
Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models
Impaired microRNA processing enhances cellular transformation and tumorigenesis
Serotonin and neuropeptide F have opposite modulatory effects on fly aggression
Genetic reconstruction of a functional transcriptional regulatory network
Corrigendum: Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species
Corrigendum: A common coding variant in CASP8 is associated with breast cancer risk
Nature GeneticsNature GeneticsGenomics of common diseases
Reactive oxygen species and the segregation of mtDNA sequence variants
Reply to ?Reactive oxygen species and the segregation of mtDNA sequence variants?
Inherited epimutation or a haplotypic basis for the propensity to silence?
Heritable germline epimutations in humans
Heritable germline epimutation is not the same as transgenerational epigenetic inheritance
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Genes get diabolical
Multiple prostate cancer risk variants on 8q24
Road rage and fruit flies
MicroRNAs as tumor suppressors
A quantitative trait locus regulating rice grain width
Touching base
Research highlights
Drosophila researchers focus on human disease
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers
Modifiers of epigenetic reprogramming show paternal effects in the mouse
A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
Multiple regions within 8q24 independently affect risk for prostate cancer
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema
Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer
Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility
Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models
Impaired microRNA processing enhances cellular transformation and tumorigenesis
Serotonin and neuropeptide F have opposite modulatory effects on fly aggression
Genetic reconstruction of a functional transcriptional regulatory network
Corrigendum: Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species
Corrigendum: A common coding variant in CASP8 is associated with breast cancer risk
Nature GeneticsNature GeneticsGenomics of common diseases
Reactive oxygen species and the segregation of mtDNA sequence variants
Reply to ?Reactive oxygen species and the segregation of mtDNA sequence variants?
Inherited epimutation or a haplotypic basis for the propensity to silence?
Heritable germline epimutations in humans
Heritable germline epimutation is not the same as transgenerational epigenetic inheritance
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Genes get diabolical
Multiple prostate cancer risk variants on 8q24
Road rage and fruit flies
MicroRNAs as tumor suppressors
A quantitative trait locus regulating rice grain width
Touching base
Research highlights
Drosophila researchers focus on human disease
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers
Modifiers of epigenetic reprogramming show paternal effects in the mouse
A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
Multiple regions within 8q24 independently affect risk for prostate cancer
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema
Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer
Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility
Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models
Impaired microRNA processing enhances cellular transformation and tumorigenesis
Serotonin and neuropeptide F have opposite modulatory effects on fly aggression
Genetic reconstruction of a functional transcriptional regulatory network
Corrigendum: Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species
Corrigendum: A common coding variant in CASP8 is associated with breast cancer risk
Nature GeneticsNature GeneticsGenomics of common diseases
Reactive oxygen species and the segregation of mtDNA sequence variants
Reply to ?Reactive oxygen species and the segregation of mtDNA sequence variants?
Inherited epimutation or a haplotypic basis for the propensity to silence?
Heritable germline epimutations in humans
Heritable germline epimutation is not the same as transgenerational epigenetic inheritance
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Reply to ?Heritable germline epimutation is not the same as transgenerational epigenetic inheritance?
Genes get diabolical
Multiple prostate cancer risk variants on 8q24
Road rage and fruit flies
MicroRNAs as tumor suppressors
A quantitative trait locus regulating rice grain width
Touching base
Research highlights
Drosophila researchers focus on human disease
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers
Modifiers of epigenetic reprogramming show paternal effects in the mouse
A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
Multiple regions within 8q24 independently affect risk for prostate cancer
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema
Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer
Homozygous mutation of AURKC yields large-headed polyploid spermatozoa and causes male infertility
Direct quantitative trait locus mapping of mammalian metabolic phenotypes in diabetic and normoglycemic rat models
Impaired microRNA processing enhances cellular transformation and tumorigenesis
Serotonin and neuropeptide F have opposite modulatory effects on fly aggression
Genetic reconstruction of a functional transcriptional regulatory network
Corrigendum: Differential translation efficiency of orthologous genes is involved in phenotypic divergence of yeast species
Corrigendum: A common coding variant in CASP8 is associated with breast cancer risk
Nature GeneticsNature GeneticsAdvancing the spark
Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection
Nature GeneticsNature GeneticsAdvancing the spark
Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection
Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection
Reply to ?Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection?
DNA double-strand breaks are not sufficient to initiate recruitment of TRF2
Reply to ?DNA double-strand breaks are not sufficient to initiate recruitment of TRF2?
A general theory of gene sharing
Ribonucleotide reductase and mitochondrial DNA synthesis
Evolutionary conservation in myoblast fusion
From fused toes in mice to human obesity
Scarce but scary
'Unleashed' natural killers hinder HIV
Touching base
Research highlights
Using FlyAtlas to identify better Drosophila melanogaster models of human disease
FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity
Variation in FTO contributes to childhood obesity and severe adult obesity
IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy
Tissue-specific transcriptional regulation has diverged significantly between human and mouse
Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1
p38? suppresses normal and cancer cell proliferation by antagonizing the JNK?c-Jun pathway
p38? MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion
A conserved molecular pathway mediates myoblast fusion in insects and vertebrates
Regulation of LANCEOLATE by miR319 is required for compound-leaf development in tomato
Root tip contact with low-phosphate media reprograms plant root architecture
Spontaneous DNA breakage in single living Escherichia coli cells
Corrigendum: A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
Nature GeneticsNature GeneticsAdvancing the spark
Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection
Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection
Reply to ?Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection?
DNA double-strand breaks are not sufficient to initiate recruitment of TRF2
Reply to ?DNA double-strand breaks are not sufficient to initiate recruitment of TRF2?
A general theory of gene sharing
Ribonucleotide reductase and mitochondrial DNA synthesis
Evolutionary conservation in myoblast fusion
From fused toes in mice to human obesity
Scarce but scary
'Unleashed' natural killers hinder HIV
Touching base
Research highlights
Using FlyAtlas to identify better Drosophila melanogaster models of human disease
FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity
Variation in FTO contributes to childhood obesity and severe adult obesity
IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy
Tissue-specific transcriptional regulation has diverged significantly between human and mouse
Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1
p38? suppresses normal and cancer cell proliferation by antagonizing the JNK?c-Jun pathway
p38? MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion
A conserved molecular pathway mediates myoblast fusion in insects and vertebrates
Regulation of LANCEOLATE by miR319 is required for compound-leaf development in tomato
Root tip contact with low-phosphate media reprograms plant root architecture
Spontaneous DNA breakage in single living Escherichia coli cells
Corrigendum: A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
Nature GeneticsNature GeneticsAdvancing the spark
Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection
Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection
Reply to ?Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection?
DNA double-strand breaks are not sufficient to initiate recruitment of TRF2
Reply to ?DNA double-strand breaks are not sufficient to initiate recruitment of TRF2?
A general theory of gene sharing
Ribonucleotide reductase and mitochondrial DNA synthesis
Evolutionary conservation in myoblast fusion
From fused toes in mice to human obesity
Scarce but scary
'Unleashed' natural killers hinder HIV
Touching base
Research highlights
Using FlyAtlas to identify better Drosophila melanogaster models of human disease
FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity
Variation in FTO contributes to childhood obesity and severe adult obesity
IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy
Tissue-specific transcriptional regulation has diverged significantly between human and mouse
Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1
p38? suppresses normal and cancer cell proliferation by antagonizing the JNK?c-Jun pathway
p38? MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion
A conserved molecular pathway mediates myoblast fusion in insects and vertebrates
Regulation of LANCEOLATE by miR319 is required for compound-leaf development in tomato
Root tip contact with low-phosphate media reprograms plant root architecture
Spontaneous DNA breakage in single living Escherichia coli cells
Corrigendum: A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
Nature GeneticsNature GeneticsAdvancing the spark
Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection
Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection
Reply to ?Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection?
DNA double-strand breaks are not sufficient to initiate recruitment of TRF2
Reply to ?DNA double-strand breaks are not sufficient to initiate recruitment of TRF2?
A general theory of gene sharing
Ribonucleotide reductase and mitochondrial DNA synthesis
Evolutionary conservation in myoblast fusion
From fused toes in mice to human obesity
Scarce but scary
'Unleashed' natural killers hinder HIV
Touching base
Research highlights
Using FlyAtlas to identify better Drosophila melanogaster models of human disease
FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity
Variation in FTO contributes to childhood obesity and severe adult obesity
IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy
Tissue-specific transcriptional regulation has diverged significantly between human and mouse
Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1
p38? suppresses normal and cancer cell proliferation by antagonizing the JNK?c-Jun pathway
p38? MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion
A conserved molecular pathway mediates myoblast fusion in insects and vertebrates
Regulation of LANCEOLATE by miR319 is required for compound-leaf development in tomato
Root tip contact with low-phosphate media reprograms plant root architecture
Spontaneous DNA breakage in single living Escherichia coli cells
Corrigendum: A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
Nature GeneticsNature GeneticsAdvancing the spark
Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection
Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection
Reply to ?Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection?
DNA double-strand breaks are not sufficient to initiate recruitment of TRF2
Reply to ?DNA double-strand breaks are not sufficient to initiate recruitment of TRF2?
A general theory of gene sharing
Ribonucleotide reductase and mitochondrial DNA synthesis
Evolutionary conservation in myoblast fusion
From fused toes in mice to human obesity
Scarce but scary
'Unleashed' natural killers hinder HIV
Touching base
Research highlights
Using FlyAtlas to identify better Drosophila melanogaster models of human disease
FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity
Variation in FTO contributes to childhood obesity and severe adult obesity
IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy
Tissue-specific transcriptional regulation has diverged significantly between human and mouse
Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1
p38? suppresses normal and cancer cell proliferation by antagonizing the JNK?c-Jun pathway
p38? MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion
A conserved molecular pathway mediates myoblast fusion in insects and vertebrates
Regulation of LANCEOLATE by miR319 is required for compound-leaf development in tomato
Root tip contact with low-phosphate media reprograms plant root architecture
Spontaneous DNA breakage in single living Escherichia coli cells
Corrigendum: A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
Nature GeneticsNature GeneticsAdvancing the spark
Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection
Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection
Reply to ?Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection?
DNA double-strand breaks are not sufficient to initiate recruitment of TRF2
Reply to ?DNA double-strand breaks are not sufficient to initiate recruitment of TRF2?
A general theory of gene sharing
Ribonucleotide reductase and mitochondrial DNA synthesis
Evolutionary conservation in myoblast fusion
From fused toes in mice to human obesity
Scarce but scary
'Unleashed' natural killers hinder HIV
Touching base
Research highlights
Using FlyAtlas to identify better Drosophila melanogaster models of human disease
FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity
Variation in FTO contributes to childhood obesity and severe adult obesity
IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy
Tissue-specific transcriptional regulation has diverged significantly between human and mouse
Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1
p38? suppresses normal and cancer cell proliferation by antagonizing the JNK?c-Jun pathway
p38? MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion
A conserved molecular pathway mediates myoblast fusion in insects and vertebrates
Regulation of LANCEOLATE by miR319 is required for compound-leaf development in tomato
Root tip contact with low-phosphate media reprograms plant root architecture
Spontaneous DNA breakage in single living Escherichia coli cells
Corrigendum: A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
Nature GeneticsNature GeneticsAdvancing the spark
Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection
Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection
Reply to ?Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection?
DNA double-strand breaks are not sufficient to initiate recruitment of TRF2
Reply to ?DNA double-strand breaks are not sufficient to initiate recruitment of TRF2?
A general theory of gene sharing
Ribonucleotide reductase and mitochondrial DNA synthesis
Evolutionary conservation in myoblast fusion
From fused toes in mice to human obesity
Scarce but scary
'Unleashed' natural killers hinder HIV
Touching base
Research highlights
Using FlyAtlas to identify better Drosophila melanogaster models of human disease
FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity
Variation in FTO contributes to childhood obesity and severe adult obesity
IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy
Tissue-specific transcriptional regulation has diverged significantly between human and mouse
Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1
p38? suppresses normal and cancer cell proliferation by antagonizing the JNK?c-Jun pathway
p38? MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion
A conserved molecular pathway mediates myoblast fusion in insects and vertebrates
Regulation of LANCEOLATE by miR319 is required for compound-leaf development in tomato
Root tip contact with low-phosphate media reprograms plant root architecture
Spontaneous DNA breakage in single living Escherichia coli cells
Corrigendum: A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
Nature GeneticsNature GeneticsAdvancing the spark
Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection
Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection
Reply to ?Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection?
DNA double-strand breaks are not sufficient to initiate recruitment of TRF2
Reply to ?DNA double-strand breaks are not sufficient to initiate recruitment of TRF2?
A general theory of gene sharing
Ribonucleotide reductase and mitochondrial DNA synthesis
Evolutionary conservation in myoblast fusion
From fused toes in mice to human obesity
Scarce but scary
'Unleashed' natural killers hinder HIV
Touching base
Research highlights
Using FlyAtlas to identify better Drosophila melanogaster models of human disease
FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity
Variation in FTO contributes to childhood obesity and severe adult obesity
IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy
Tissue-specific transcriptional regulation has diverged significantly between human and mouse
Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1
p38? suppresses normal and cancer cell proliferation by antagonizing the JNK?c-Jun pathway
p38? MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion
A conserved molecular pathway mediates myoblast fusion in insects and vertebrates
Regulation of LANCEOLATE by miR319 is required for compound-leaf development in tomato
Root tip contact with low-phosphate media reprograms plant root architecture
Spontaneous DNA breakage in single living Escherichia coli cells
Corrigendum: A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
Nature GeneticsNature GeneticsAdvancing the spark
Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection
Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection
Reply to ?Lack of support for an association between CLEC4M homozygosity and protection against SARS coronavirus infection?
DNA double-strand breaks are not sufficient to initiate recruitment of TRF2
Reply to ?DNA double-strand breaks are not sufficient to initiate recruitment of TRF2?
A general theory of gene sharing
Ribonucleotide reductase and mitochondrial DNA synthesis
Evolutionary conservation in myoblast fusion
From fused toes in mice to human obesity
Scarce but scary
'Unleashed' natural killers hinder HIV
Touching base
Research highlights
Using FlyAtlas to identify better Drosophila melanogaster models of human disease
FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity
Variation in FTO contributes to childhood obesity and severe adult obesity
IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy
Tissue-specific transcriptional regulation has diverged significantly between human and mouse
Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1
p38? suppresses normal and cancer cell proliferation by antagonizing the JNK?c-Jun pathway
p38? MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion
A conserved molecular pathway mediates myoblast fusion in insects and vertebrates
Regulation of LANCEOLATE by miR319 is required for compound-leaf development in tomato
Root tip contact with low-phosphate media reprograms plant root architecture
Spontaneous DNA breakage in single living Escherichia coli cells
Corrigendum: A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference
Nature GeneticsNature GeneticsGuilt beyond a reasonable doubt
Conjuring SNPs to detect associations
ENCODE and our very busy genome
Clinical variability in ciliary disorders
Wnt signaling in focal dermal hypoplasia
Touching base
Research highlights
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
Deficiency of PORCN, a regulator of Wnt signaling, is associated with focal dermal hypoplasia
Mutations in X-linked PORCN, a putative regulator of Wnt signaling, cause focal dermal hypoplasia
Comparative genomic analysis of three Leishmania species that cause diverse human disease
Intra- and intercellular RNA interference in Arabidopsis thaliana requires components of the microRNA and heterochromatic silencing pathways
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor?positive breast cancer
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome
Mutations in the gene encoding the basal body protein RPGRIP1L, a nephrocystin-4 interactor, cause Joubert syndrome
Mutations in LCA5, encoding the ciliary protein lebercilin, cause Leber congenital amaurosis
Natural variation for sulfate content in Arabidopsis thaliana is highly controlled by APR2
A conserved microRNA module exerts homeotic control over Petunia hybrida and Antirrhinum majus floral organ identity
A new multipoint method for genome-wide association studies by imputation of genotypes
Tissue-specific and reversible RNA interference in transgenic mice
Toward simpler and faster genome-wide mutagenesis in mice
Nature, genetics and the Niven factor
On the design and analysis of gene expression studies in human populations
Reply to ?On the design and analysis of gene expression studies in human populations?
The spandrels of the genome
Nature GeneticsNature GeneticsGuilt beyond a reasonable doubt
Conjuring SNPs to detect associations
ENCODE and our very busy genome
Clinical variability in ciliary disorders
Wnt signaling in focal dermal hypoplasia
Touching base
Research highlights
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
Deficiency of PORCN, a regulator of Wnt signaling, is associated with focal dermal hypoplasia
Mutations in X-linked PORCN, a putative regulator of Wnt signaling, cause focal dermal hypoplasia
Comparative genomic analysis of three Leishmania species that cause diverse human disease
Intra- and intercellular RNA interference in Arabidopsis thaliana requires components of the microRNA and heterochromatic silencing pathways
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor?positive breast cancer
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer
The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome
Mutations in the gene encoding the basal body protein RPGRIP1L, a nephrocystin-4 interactor, cause Joubert syndrome
Mutations in LCA5, encoding the ciliary protein lebercilin, cause Leber congenital amaurosis
Natural variation for sulfate content in Arabidopsis thaliana is highly controlled by APR2
A conserved microRNA module exerts homeotic control over Petunia hybrida and Antirrhinum majus floral organ identity
A new multipoint method for genome-wide association studies by imputation of genotypes
Tissue-specific and reversible RNA interference in transgenic mice
Toward simpler and faster genome-wide mutagenesis in mice
Nature, genetics and the Niven factor
On the design and analysis of gene expression studies in human populations
Reply to ?On the design and analysis of gene expression studies in human populations?
The spandrels of the genome
Nature GeneticsNature GeneticsCompete, collaborate, compel
Splinkerette PCR for more efficient characterization of gene trap events
Target mimics modulate miRNAs
Axons need glial peroxisomes
A step forward for restless legs syndrome
Touching base
Research Highlights
Evolution of chromosome organization driven by selection for reduced gene expression noise
Common variants in WFS1 confer risk of type 2 diabetes
A common genetic risk factor for colorectal and prostate cancer
Mutations in LRP2, which encodes the multiligand receptor megalin, cause Donnai-Barrow and facio-oculo-acoustico-renal syndromes
Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL
Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth
Bi-orientation of achiasmatic chromosomes in meiosis I oocytes contributes to aneuploidy in mice
Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21
Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24
A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease
Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions
Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy
Germline gain-of-function mutations in RAF1 cause Noonan syndrome
Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis
Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice
Target mimicry provides a new mechanism for regulation of microRNA activity
Nature GeneticsNature GeneticsCompete, collaborate, compel
Splinkerette PCR for more efficient characterization of gene trap events
Target mimics modulate miRNAs
Axons need glial peroxisomes
A step forward for restless legs syndrome
Touching base
Research Highlights
Evolution of chromosome organization driven by selection for reduced gene expression noise
Common variants in WFS1 confer risk of type 2 diabetes
A common genetic risk factor for colorectal and prostate cancer
Mutations in LRP2, which encodes the multiligand receptor megalin, cause Donnai-Barrow and facio-oculo-acoustico-renal syndromes
Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL
Nature GeneticsNature GeneticsCompete, collaborate, compel
Splinkerette PCR for more efficient characterization of gene trap events
Target mimics modulate miRNAs
Axons need glial peroxisomes
A step forward for restless legs syndrome
Touching base
Research Highlights
Evolution of chromosome organization driven by selection for reduced gene expression noise
Common variants in WFS1 confer risk of type 2 diabetes
A common genetic risk factor for colorectal and prostate cancer
Mutations in LRP2, which encodes the multiligand receptor megalin, cause Donnai-Barrow and facio-oculo-acoustico-renal syndromes
Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL
Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth
Bi-orientation of achiasmatic chromosomes in meiosis I oocytes contributes to aneuploidy in mice
Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21
Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24
A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease
Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions
Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy
Germline gain-of-function mutations in RAF1 cause Noonan syndrome
Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis
Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice
Target mimicry provides a new mechanism for regulation of microRNA activity
Nature GeneticsNature GeneticsCompete, collaborate, compel
Splinkerette PCR for more efficient characterization of gene trap events
Target mimics modulate miRNAs
Axons need glial peroxisomes
A step forward for restless legs syndrome
Touching base
Research Highlights
Evolution of chromosome organization driven by selection for reduced gene expression noise
Common variants in WFS1 confer risk of type 2 diabetes
A common genetic risk factor for colorectal and prostate cancer
Mutations in LRP2, which encodes the multiligand receptor megalin, cause Donnai-Barrow and facio-oculo-acoustico-renal syndromes
Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL
Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth
Bi-orientation of achiasmatic chromosomes in meiosis I oocytes contributes to aneuploidy in mice
Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21
Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24
A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease
Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions
Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy
Germline gain-of-function mutations in RAF1 cause Noonan syndrome
Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis
Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice
Target mimicry provides a new mechanism for regulation of microRNA activity
Nature GeneticsNature GeneticsAmerica competes?for now
Anne McLaren 1927?2007
Patchwork women
New models of collaboration in genome-wide association studies: the Genetic Association Information Network
IL-7R? and multiple sclerosis risk
A haplotype map for the laboratory mouse
An Arabidopsis haplotype map takes root
Cancer drugs to treat birth defects
Touching base
Research Highlights
Mutations in the gene encoding the 3?-5? DNA exonuclease TREX1 are associated with systemic lupus erythematosus
C-terminal truncations in human 3?-5? DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy
Discovery of a previously unrecognized microdeletion syndrome of 16p11.2?p12.2
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes
Interleukin 7 receptor ? chain (IL7R) shows allelic and functional association with multiple sclerosis
Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans
On the subspecific origin of the laboratory mouse
Variation in interleukin 7 receptor ? chain (IL7R) influences risk of multiple sclerosis
Global diversity and evidence for coevolution of KIR and HLA
Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1?like phenotype
Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation
Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy
Promoter regions of many neural- and nutrition-related genes have experienced positive selection during human evolution
RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis
Recombination and linkage disequilibrium in Arabidopsis thaliana
A gene in the multidrug and toxic compound extrusion (MATE) family confers aluminum tolerance in sorghum
A single positively selected West Nile viral mutation confers increased virogenesis in American crows
Bayesian inference of epistatic interactions in case-control studies
Corrigendum: Spontaneous DNA breakage in single living Escherichia coli cells
Corrigendum: Genome-wide analysis of mammalian promoter architecture and evolution
Nature GeneticsNature GeneticsAmerica competes?for now
Anne McLaren 1927?2007
Patchwork women
New models of collaboration in genome-wide association studies: the Genetic Association Information Network
IL-7R? and multiple sclerosis risk
A haplotype map for the laboratory mouse
An Arabidopsis haplotype map takes root
Cancer drugs to treat birth defects
Touching base
Research Highlights
Mutations in the gene encoding the 3?-5? DNA exonuclease TREX1 are associated with systemic lupus erythematosus
C-terminal truncations in human 3?-5? DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy
Discovery of a previously unrecognized microdeletion syndrome of 16p11.2?p12.2
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes
Interleukin 7 receptor ? chain (IL7R) shows allelic and functional association with multiple sclerosis
Unusual selection on the KIR3DL1/S1 natural killer cell receptor in Africans
On the subspecific origin of the laboratory mouse
Variation in interleukin 7 receptor ? chain (IL7R) influences risk of multiple sclerosis
Global diversity and evidence for coevolution of KIR and HLA
Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1?like phenotype
Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation
Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy
Promoter regions of many neural- and nutrition-related genes have experienced positive selection during human evolution
RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis
Recombination and linkage disequilibrium in Arabidopsis thaliana
A gene in the multidrug and toxic compound extrusion (MATE) family confers aluminum tolerance in sorghum
A single positively selected West Nile viral mutation confers increased virogenesis in American crows
Bayesian inference of epistatic interactions in case-control studies
Corrigendum: Spontaneous DNA breakage in single living Escherichia coli cells
Corrigendum: Genome-wide analysis of mammalian promoter architecture and evolution
Nature GeneticsNature GeneticsPinpointing expression differences
Marcy Carlson Speer 1959?2007
A textbook for all seasons
The NCBI dbGaP database of genotypes and phenotypes
Rescuing distal crossovers
Adaptive drool in the gene pool
Rhythm is not enough
How microRNAs choose their targets
Touching base
Research Highlights
A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15
Variation in complement factor 3 is associated with risk of age-related macular degeneration
A genome-wide association study of global gene expression
Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes
Population genomics of human gene expression
Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family?mediated transcriptional activation of TGF?2
A high-resolution atlas of nucleosome occupancy in yeast
A common variant of HMGA2 is associated with adult and childhood height in the general population
Measurement of the human allele frequency spectrum demonstrates greater genetic drift in East Asians than in Europeans
Diet and the evolution of human amylase gene copy number variation
Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans
The imprinted gene Magel2 regulates normal circadian output
The spindle checkpoint rescues the meiotic segregation of chromosomes whose crossovers are far from the centromere
The role of site accessibility in microRNA target recognition
Corrigendum: Mapping autism risk loci using genetic linkage and chromosomal rearrangements
Corrigendum: Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning
Corrigendum: Variation in FTO contributes to childhood obesity and severe adult obesity
Nature GeneticsNature GeneticsPinpointing expression differences
Marcy Carlson Speer 1959?2007
A textbook for all seasons
The NCBI dbGaP database of genotypes and phenotypes
Rescuing distal crossovers
Adaptive drool in the gene pool
Rhythm is not enough
How microRNAs choose their targets
Touching base
Research Highlights
A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15
Variation in complement factor 3 is associated with risk of age-related macular degeneration
A genome-wide association study of global gene expression
Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes
Population genomics of human gene expression
Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family?mediated transcriptional activation of TGF?2
A high-resolution atlas of nucleosome occupancy in yeast
A common variant of HMGA2 is associated with adult and childhood height in the general population
Measurement of the human allele frequency spectrum demonstrates greater genetic drift in East Asians than in Europeans
Diet and the evolution of human amylase gene copy number variation
Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans
The imprinted gene Magel2 regulates normal circadian output
The spindle checkpoint rescues the meiotic segregation of chromosomes whose crossovers are far from the centromere
The role of site accessibility in microRNA target recognition
Corrigendum: Mapping autism risk loci using genetic linkage and chromosomal rearrangements
Corrigendum: Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning
Corrigendum: Variation in FTO contributes to childhood obesity and severe adult obesity
Nature GeneticsNature GeneticsDeveloping genetics for developing countries
Erasure of MLH1 methylation in spermatozoa?implications for epigenetic inheritance
DNA and aging
Islamic ethical framework for research into and prevention of genetic diseases
A gene harvest revealing the archeology and complexity of human disease
Double Dutch for duplications
How the dog got its spots
Aging and cancer: killing two birds with one worm
Building in resistance to endothelial cell death
Red sky in the morning, shepherd's warning
Touching Base
Research highlights
A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk
Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs
Efficient mapping of mendelian traits in dogs through genome-wide association
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
Network modeling links breast cancer susceptibility and centrosome dysfunction
Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response
Ancestral reconstruction of segmental duplications reveals punctuated cores of human genome evolution
Genetic basis of proteome variation in yeast
EphB?ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells
Recurrent DNA copy number variation in the laboratory mouse
Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein
Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis
DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans
Light-quality regulation of freezing tolerance in Arabidopsis thaliana
Addendum: Germline epimutation of MLH1 in individuals with multiple cancers
Nature GeneticsNature GeneticsDeveloping genetics for developing countries
Erasure of MLH1 methylation in spermatozoa?implications for epigenetic inheritance
DNA and aging
Islamic ethical framework for research into and prevention of genetic diseases
A gene harvest revealing the archeology and complexity of human disease
Double Dutch for duplications
How the dog got its spots
Aging and cancer: killing two birds with one worm
Building in resistance to endothelial cell death
Red sky in the morning, shepherd's warning
Touching Base
Research highlights
A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk
Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs
Efficient mapping of mendelian traits in dogs through genome-wide association
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
Network modeling links breast cancer susceptibility and centrosome dysfunction
Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response
Ancestral reconstruction of segmental duplications reveals punctuated cores of human genome evolution
Genetic basis of proteome variation in yeast
EphB?ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cells
Recurrent DNA copy number variation in the laboratory mouse
Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein
Birc2 (cIap1) regulates endothelial cell integrity and blood vessel homeostasis
DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans
Light-quality regulation of freezing tolerance in Arabidopsis thaliana
Addendum: Germline epimutation of MLH1 in individuals with multiple cancers
Nature GeneticsNature GeneticsRisky business
John Hilton Edwards 1928?2007
Hairs and heirs
Stalled polymerases and transcriptional regulation
Sudden and unexpected
High-maintenance proteins and hypertriglyceridemia
Two sides of the same coin
Touching base
Research highlights
Rheumatoid arthritis association at 6q23
Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11
Cystatin C modulates cerebral ?-amyloidosis
Cystatin C inhibits amyloid-? deposition in Alzheimer's disease mouse models
Genetic determinants of hair, eye and skin pigmentation in Europeans
ATP-sensitive potassium channels mediate survival during infection in mammals and insects
Dynamic evolution of the innate immune system in Drosophila
Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia
Mutations in smooth muscle ?-actin (ACTA2) lead to thoracic aortic aneurysms and dissections
A survey of genetic human cortical gene expression
Loss of Trim24 (Tif1?) gene function confers oncogenic activity to retinoic acid receptor alpha
RNA polymerase is poised for activation across the genome
RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo
The maize tasselseed4 microRNA controls sex determination and meristem cell fate by targeting Tasselseed6/indeterminate spikelet1
Genome-wide in situ exon capture for selective resequencing
Erratum: Splinkerette PCR for more efficient characterization of gene trap events
Nature GeneticsNature GeneticsRisky business
John Hilton Edwards 1928?2007
Hairs and heirs
Stalled polymerases and transcriptional regulation
Sudden and unexpected
High-maintenance proteins and hypertriglyceridemia
Two sides of the same coin
Touching base
Research highlights
Rheumatoid arthritis association at 6q23
Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11
Cystatin C modulates cerebral ?-amyloidosis
Cystatin C inhibits amyloid-? deposition in Alzheimer's disease mouse models
Genetic determinants of hair, eye and skin pigmentation in Europeans
ATP-sensitive potassium channels mediate survival during infection in mammals and insects
Dynamic evolution of the innate immune system in Drosophila
Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia
Mutations in smooth muscle ?-actin (ACTA2) lead to thoracic aortic aneurysms and dissections
A survey of genetic human cortical gene expression
Loss of Trim24 (Tif1?) gene function confers oncogenic activity to retinoic acid receptor alpha
RNA polymerase is poised for activation across the genome
RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo
The maize tasselseed4 microRNA controls sex determination and meristem cell fate by targeting Tasselseed6/indeterminate spikelet1
Genome-wide in situ exon capture for selective resequencing
Erratum: Splinkerette PCR for more efficient characterization of gene trap events
Nature GeneticsNature GeneticsHuman Variome Microattribution Reviews
Trial and error
Copy-number analysis goes more than skin deep
Genomic rearrangements in the spotlight
BRCA1?sowing the seeds crooked in the furrow
Basal bodies, kinocilia and planar cell polarity
Touching base
Research highlights
The emerging landscape of breast cancer susceptibility
Psoriasis is associated with increased ?-defensin genomic copy number
Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk
Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis
Impaired glycosylation and cutis laxa caused by mutations in the vesicular H -ATPase subunit ATP6V0A2
ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms
Widespread microRNA repression by Myc contributes to tumorigenesis
PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis
RNA toxicity in myotonic muscular dystrophy induces NKX2-5 expression
Ciliary proteins link basal body polarization to planar cell polarity regulation
Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis
Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus
Germline rates of de novo meiotic deletions and duplications causing several genomic disorders
Closing gaps in the human genome with fosmid resources generated from multiple individuals
Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair
AID is required for germinal center?derived lymphomagenesis
Identification and characterization of high-flux-control genes of yeast through competition analyses in continuous cultures
Nature GeneticsNature GeneticsHuman Variome Microattribution Reviews
Trial and error
Copy-number analysis goes more than skin deep
Genomic rearrangements in the spotlight
BRCA1?sowing the seeds crooked in the furrow
Basal bodies, kinocilia and planar cell polarity
Touching base
Research highlights
The emerging landscape of breast cancer susceptibility
Psoriasis is associated with increased ?-defensin genomic copy number
Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk
Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis
Impaired glycosylation and cutis laxa caused by mutations in the vesicular H -ATPase subunit ATP6V0A2
ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms
Widespread microRNA repression by Myc contributes to tumorigenesis
PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis
RNA toxicity in myotonic muscular dystrophy induces NKX2-5 expression
Ciliary proteins link basal body polarization to planar cell polarity regulation
Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis
Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus
Germline rates of de novo meiotic deletions and duplications causing several genomic disorders
Closing gaps in the human genome with fosmid resources generated from multiple individuals
Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair
AID is required for germinal center?derived lymphomagenesis
Identification and characterization of high-flux-control genes of yeast through competition analyses in continuous cultures
Nature GeneticsNature GeneticsPositively disruptive
Seymour Benzer 1921?2007
Islamic principles and decision making in bioethics
A navigator for human genome epidemiology
A genetic view of Jewish history
A treasure trove for lipoprotein biology
The developing mosaic of autoimmune disease risk
Hypoxic reprogramming
Two ways to make an mtDNA bottleneck
Touching base
Research highlights
Epigenetic regulation and the variability of gene expression
Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides
A nonsynonymous functional variant in integrin-?M (encoded by ITGAM) is associated with systemic lupus erythematosus
Mutations in mRNA export mediator GLE1 result in a fetal motoneuron disease
Ultraconservation identifies a small subset of extremely constrained developmental enhancers
Newly identified loci that influence lipid concentrations and risk of coronary artery disease
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism
A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
Common variants in the GDF5-UQCC region are associated with variation in human height
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
Genome-wide analysis of transcript isoform variation in humans
Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling
Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes
Role of retrotransposon-derived imprinted gene, Rtl1, in the feto-maternal interface of mouse placenta
A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes
Erratum: PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis
Erratum: Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11
Corrigendum: Mutations in smooth muscle ?-actin (ACTA2) lead to thoracic aortic aneurysms and dissections
Nature GeneticsNature GeneticsPositively disruptive
Seymour Benzer 1921?2007
Islamic principles and decision making in bioethics
A navigator for human genome epidemiology
A genetic view of Jewish history
A treasure trove for lipoprotein biology
The developing mosaic of autoimmune disease risk
Hypoxic reprogramming
Two ways to make an mtDNA bottleneck
Touching base
Research highlights
Epigenetic regulation and the variability of gene expression
Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides
A nonsynonymous functional variant in integrin-?M (encoded by ITGAM) is associated with systemic lupus erythematosus
Mutations in mRNA export mediator GLE1 result in a fetal motoneuron disease
Ultraconservation identifies a small subset of extremely constrained developmental enhancers
Newly identified loci that influence lipid concentrations and risk of coronary artery disease
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism
A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
Common variants in the GDF5-UQCC region are associated with variation in human height
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
Genome-wide analysis of transcript isoform variation in humans
Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling
Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes
Role of retrotransposon-derived imprinted gene, Rtl1, in the feto-maternal interface of mouse placenta
A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes
Erratum: PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis
Erratum: Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11
Corrigendum: Mutations in smooth muscle ?-actin (ACTA2) lead to thoracic aortic aneurysms and dissections
Nature GeneticsNature GeneticsPositively disruptive
Seymour Benzer 1921?2007
Islamic principles and decision making in bioethics
A navigator for human genome epidemiology
A genetic view of Jewish history
A treasure trove for lipoprotein biology
The developing mosaic of autoimmune disease risk
Hypoxic reprogramming
Two ways to make an mtDNA bottleneck
Touching base
Research highlights
Epigenetic regulation and the variability of gene expression
Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides
A nonsynonymous functional variant in integrin-?M (encoded by ITGAM) is associated with systemic lupus erythematosus
Mutations in mRNA export mediator GLE1 result in a fetal motoneuron disease
Ultraconservation identifies a small subset of extremely constrained developmental enhancers
Newly identified loci that influence lipid concentrations and risk of coronary artery disease
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism
A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
Common variants in the GDF5-UQCC region are associated with variation in human height
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci
Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm
Genome-wide analysis of transcript isoform variation in humans
Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling
Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes
Role of retrotransposon-derived imprinted gene, Rtl1, in the feto-maternal interface of mouse placenta
A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes
Erratum: PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis
Erratum: Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11
Corrigendum: Mutations in smooth muscle ?-actin (ACTA2) lead to thoracic aortic aneurysms and dissections
Nature GeneticsNature GeneticsRisk loci, biological candidates and biomarkers
A promoter polymorphism in the CASP8 gene is not associated with cancer risk
Reply to ?A promoter polymorphism in the CASP8 gene is not associated with cancer risk?
Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations
Reply to ?Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations?
Disentangling the roots of inherited hair disorders
Division of labor among meiotic genes
MicroRNAs in facial development
Plant breeders go back to nature
Research highlights
What causes mitochondrial DNA deletions in human cells?
Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer
Thromboxane synthase mutations in an increased bone density disorder (Ghosal syndrome)
Mutations in the cyclin family member FAM58A cause an X-linked dominant disorder characterized by syndactyly, telecanthus and anogenital and renal malformations
MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis
Crossover assurance and crossover interference are distinctly regulated by the ZMM proteins during yeast meiosis
Multiple loci identified in a genome-wide association study of prostate cancer
Multiple newly identified loci associated with prostate cancer susceptibility
A recurrent 15q13.3 microdeletion syndrome associated with mental retardation and seizures
G protein?coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth
Disruption of P2RY5, an orphan G protein?coupled receptor, underlies autosomal recessive woolly hair
Natural selection has driven population differentiation in modern humans
Regulatory changes underlying expression differences within and between Drosophila species
The birth and death of microRNA genes in Drosophila
Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint
Unprotected Drosophila melanogaster telomeres activate the spindle assembly checkpoint
A phenylalanine in DGAT is a key determinant of oil content and composition in maize
Corrigendum: Regional copy number?independent deregulation of transcription in cancer
Nature GeneticsNature GeneticsRisk loci, biological candidates and biomarkers
A promoter polymorphism in the CASP8 gene is not associated with cancer risk
Reply to ?A promoter polymorphism in the CASP8 gene is not associated with cancer risk?
Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations
Reply to ?Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations?
Disentangling the roots of inherited hair disorders
Division of labor among meiotic genes
MicroRNAs in facial development
Plant breeders go back to nature
Research highlights
What causes mitochondrial DNA deletions in human cells?
Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer
Thromboxane synthase mutations in an increased bone density disorder (Ghosal syndrome)
Mutations in the cyclin family member FAM58A cause an X-linked dominant disorder characterized by syndactyly, telecanthus and anogenital and renal malformations
MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis
Crossover assurance and crossover interference are distinctly regulated by the ZMM proteins during yeast meiosis
Multiple loci identified in a genome-wide association study of prostate cancer
Multiple newly identified loci associated with prostate cancer susceptibility
A recurrent 15q13.3 microdeletion syndrome associated with mental retardation and seizures
G protein?coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth
Disruption of P2RY5, an orphan G protein?coupled receptor, underlies autosomal recessive woolly hair
Natural selection has driven population differentiation in modern humans
Regulatory changes underlying expression differences within and between Drosophila species
The birth and death of microRNA genes in Drosophila
Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint
Unprotected Drosophila melanogaster telomeres activate the spindle assembly checkpoint
A phenylalanine in DGAT is a key determinant of oil content and composition in maize
Corrigendum: Regional copy number?independent deregulation of transcription in cancer
Nature GeneticsNature GeneticsDesegregating science and the public
A cultural historian's history of biology
Re-examining the role of cytochrome c in cell death
Adding pathogens by genomic subtraction
HIV-1 positive feedback and lytic fate
Delivery codes for fly transgenics
Research highlights
A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia
Evolutionary plasticity of genetic interaction networks
DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice
Newly identified genetic risk variants for celiac disease related to the immune response
THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia
PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos
Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids
SLC2A9 influences uric acid concentrations with pronounced sex-specific effects
SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout
Hypomorphic mutations in syndromic encephalocele genes are associated with Bardet-Biedl syndrome
Highly effective SNP-based association mapping and management of recessive defects in livestock
LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis
Newly identified prion linked to the chromatin-remodeling factor Swi1 in Saccharomyces cerevisiae
Transient-mediated fate determination in a transcriptional circuit of HIV
Stochastic switching as a survival strategy in fluctuating environments
Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes
Corrigendum: Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus
Salome Gluecksohn-Waelsch 1907?2007
Nature GeneticsNature GeneticsDesegregating science and the public
A cultural historian's history of biology
Re-examining the role of cytochrome c in cell death
Adding pathogens by genomic subtraction
HIV-1 positive feedback and lytic fate
Delivery codes for fly transgenics
Research highlights
A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia
Evolutionary plasticity of genetic interaction networks
DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice
Newly identified genetic risk variants for celiac disease related to the immune response
THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia
PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos
Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids
SLC2A9 influences uric acid concentrations with pronounced sex-specific effects
SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout
Hypomorphic mutations in syndromic encephalocele genes are associated with Bardet-Biedl syndrome
Highly effective SNP-based association mapping and management of recessive defects in livestock
LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis
Newly identified prion linked to the chromatin-remodeling factor Swi1 in Saccharomyces cerevisiae
Transient-mediated fate determination in a transcriptional circuit of HIV
Stochastic switching as a survival strategy in fluctuating environments
Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes
Corrigendum: Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus
Salome Gluecksohn-Waelsch 1907?2007
Nature GeneticsNature GeneticsStarting well in Europe
Year of the Rat
An ENU-induced mutant archive for gene targeting in rats
What everybody should know about the rat genome and its online resources
The beginning of the ends
Sizing up human height variation
Principal component analysis of genetic data
From gene expression to disease risk
Coevolution in the tumor microenvironment
Salt wasting and blood pressure
Research Highlights
Progress and prospects in rat genetics: a community view
Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)
TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease
Distribution and functional impact of DNA copy number variation in the rat
Genome-wide association analysis identifies 20 loci that influence adult height
Identification of ten loci associated with height highlights new biological pathways in human growth
Rare independent mutations in renal salt handling genes contribute to blood pressure variation
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon
Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass
Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility
Many sequence variants affecting diversity of adult human height
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Interpreting principal component analyses of spatial population genetic variation
No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas
Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal ?? T cells
SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation
A structural-maintenance-of-chromosomes hinge domain?containing protein is required for RNA-directed DNA methylation
Exposing the fitness contribution of duplicated genes
SNP and haplotype mapping for genetic analysis in the rat
Erratum: Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids
Joshua Lederberg 1925?2008
An embryonic stem cell?like gene expression signature in poorly differentiated aggressive human tumors
Nature GeneticsNature GeneticsStarting well in Europe
Year of the Rat
An ENU-induced mutant archive for gene targeting in rats
What everybody should know about the rat genome and its online resources
The beginning of the ends
Sizing up human height variation
Principal component analysis of genetic data
From gene expression to disease risk
Coevolution in the tumor microenvironment
Salt wasting and blood pressure
Research Highlights
Progress and prospects in rat genetics: a community view
Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)
TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease
Distribution and functional impact of DNA copy number variation in the rat
Genome-wide association analysis identifies 20 loci that influence adult height
Identification of ten loci associated with height highlights new biological pathways in human growth
Rare independent mutations in renal salt handling genes contribute to blood pressure variation
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon
Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass
Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility
Many sequence variants affecting diversity of adult human height
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Interpreting principal component analyses of spatial population genetic variation
No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas
Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal ?? T cells
SmcHD1, containing a structural-maintenance-of-chromosomes hinge domain, has a critical role in X inactivation
A structural-maintenance-of-chromosomes hinge domain?containing protein is required for RNA-directed DNA methylation
Exposing the fitness contribution of duplicated genes
SNP and haplotype mapping for genetic analysis in the rat
Erratum: Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids
Joshua Lederberg 1925?2008
An embryonic stem cell?like gene expression signature in poorly differentiated aggressive human tumors
Nature GeneticsNature GeneticsFrom X-rays to aging
A timely guide to the genome
Molecular screening for new fusion genes in cancer
New susceptibility genes for ulcerative colitis
Prader-Willi and snoRNAs
The not-so-silent X
The hippocratic finger points the blame at PGE2
Research Highlights
Common and rare variants in multifactorial susceptibility to common diseases
Common variants on chromosome 5p12 confer susceptibility to estrogen receptor?positive breast cancer
Multiple ADH genes are associated with upper aerodigestive cancers
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis
Common genetic variation near MC4R is associated with waist circumference and insulin resistance
Prader-Willi phenotype caused by paternal deficiency for the HBII-85 C/D box small nucleolar RNA cluster
Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing
Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer
Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model
Natural variation in Ghd7 is an important regulator of heading date and yield potential in rice
Common variants near MC4R are associated with fat mass, weight and risk of obesity
X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment
De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy
Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy
The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expression
Regulatory change in YABBY-like transcription factor led to evolution of extreme fruit size during tomato domestication
Nature GeneticsNature GeneticsFrom X-rays to aging
A timely guide to the genome
Molecular screening for new fusion genes in cancer
New susceptibility genes for ulcerative colitis
Prader-Willi and snoRNAs
The not-so-silent X
The hippocratic finger points the blame at PGE2
Research Highlights
Common and rare variants in multifactorial susceptibility to common diseases
Common variants on chromosome 5p12 confer susceptibility to estrogen receptor?positive breast cancer
Multiple ADH genes are associated with upper aerodigestive cancers
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis
Common genetic variation near MC4R is associated with waist circumference and insulin resistance
Prader-Willi phenotype caused by paternal deficiency for the HBII-85 C/D box small nucleolar RNA cluster
Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing
Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer
Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model
Natural variation in Ghd7 is an important regulator of heading date and yield potential in rice
Common variants near MC4R are associated with fat mass, weight and risk of obesity
X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment
De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy
Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy
The mouse X chromosome is enriched for multicopy testis genes showing postmeiotic expression
Regulatory change in YABBY-like transcription factor led to evolution of extreme fruit size during tomato domestication
Nature GeneticsNature GeneticsAll in the mind
ESR1 gene amplification in breast cancer: a common phenomenon?
Reply to ?ESR1 gene amplification in breast cancer: a common phenomenon??
Nature GeneticsNature GeneticsAll in the mind
ESR1 gene amplification in breast cancer: a common phenomenon?
Reply to ?ESR1 gene amplification in breast cancer: a common phenomenon??
ESR1 gene amplification in breast cancer: a common phenomenon?
HDAC2 deficiency and histone acetylation
ESR1 gene amplification in breast cancer: a common phenomenon?
Reply to ?HDAC2 deficiency and histone acetylation?
ESR1 gene amplification in breast cancer: a common phenomenon?
Blood-strong love
Research highlights
Conflicting evidence on the frequency of ESR1 amplification in breast cancer
Bringing age-related macular degeneration into focus
A new identity for the elusive intestinal stem cell
Lung stem cells in the balance
Shedding light on skin cancer
Estimating coverage and power for genetic association studies using near-complete variation data
Common sequence variants on 20q11.22 confer melanoma susceptibility
Two newly identified genetic determinants of pigmentation in Europeans
NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer
Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells
A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration
Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks
Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA
ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma
Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation
Ras-MAPK signaling promotes trophectoderm formation from embryonic stem cells and mouse embryos
Bmi1 is expressed in vivo in intestinal stem cells
Mouse segmental duplication and copy number variation
Combinatorial patterns of histone acetylations and methylations in the human genome
Strong association of de novo copy number mutations with sporadic schizophrenia
Corrigendum: Prolyl 3-hydroxylase 1 deficiency causes a recessive metabolic bone disorder resembling lethal/severe osteogenesis imperfecta
Corrigendum: Hypomorphic mutations in syndromic encephalocele genes are associated with Bardet-Biedl syndrome
Corrigendum: Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database
Giuseppe Attardi 1923?2008
Nature GeneticsNature GeneticsFrom risk to function
Putting science over supposition in the arena of personalized genomics
Famed biologist lost to Stalin's terror
Research highlights
H19 in the pouch
One PRDM is not enough for germ cell development
Mapping the strand-specific transcriptome of fission yeast
Dark skin mutations shed light on inherited anemia
Common nonsynonymous variants in PCSK1 confer risk of obesity
Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57
Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension
PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
Dynamic transcriptome of Schizosaccharomyces pombe shown by RNA-DNA hybrid mapping
High-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi
Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects
Conservation of the H19 noncoding RNA and H19-IGF2 imprinting mechanism in therians
Common variants in DVWA on chromosome 3p24.3 are associated with susceptibility to knee osteoarthritis
Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia
A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse
Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease
Deletion in a gene associated with grain size increased yields during rice domestication
Critical function of Prdm14 for the establishment of the germ cell lineage in mice
Corrigendum: ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma
Nature GeneticsNature GeneticsFrom risk to function
Putting science over supposition in the arena of personalized genomics
Famed biologist lost to Stalin's terror
Research highlights
H19 in the pouch
One PRDM is not enough for germ cell development
Mapping the strand-specific transcriptome of fission yeast
Dark skin mutations shed light on inherited anemia
Common nonsynonymous variants in PCSK1 confer risk of obesity
Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57
Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension
PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
Dynamic transcriptome of Schizosaccharomyces pombe shown by RNA-DNA hybrid mapping
High-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi
Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects
Conservation of the H19 noncoding RNA and H19-IGF2 imprinting mechanism in therians
Common variants in DVWA on chromosome 3p24.3 are associated with susceptibility to knee osteoarthritis
Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia
A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse
Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease
Deletion in a gene associated with grain size increased yields during rice domestication
Critical function of Prdm14 for the establishment of the germ cell lineage in mice
Corrigendum: ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma
Nature GeneticsNature GeneticsFrom risk to function
Putting science over supposition in the arena of personalized genomics
Famed biologist lost to Stalin's terror
Research highlights
H19 in the pouch
One PRDM is not enough for germ cell development
Mapping the strand-specific transcriptome of fission yeast
Dark skin mutations shed light on inherited anemia
Common nonsynonymous variants in PCSK1 confer risk of obesity
Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57
Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension
PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
Dynamic transcriptome of Schizosaccharomyces pombe shown by RNA-DNA hybrid mapping
High-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi
Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects
Conservation of the H19 noncoding RNA and H19-IGF2 imprinting mechanism in therians
Common variants in DVWA on chromosome 3p24.3 are associated with susceptibility to knee osteoarthritis
Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia
A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse
Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease
Deletion in a gene associated with grain size increased yields during rice domestication
Critical function of Prdm14 for the establishment of the germ cell lineage in mice
Corrigendum: ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma
Nature GeneticsNature GeneticsBack to basics in Berlin
Variation in KLK genes, prostate-specific antigen and risk of prostate cancer
Reply to ?Variation in KLK genes, prostate-specific antigen and risk of prostate cancer?
High anxiety
Research highlights
Psychiatric genetics gets a boost
Casting a wider net for diabetes susceptibility genes
Hedgehog in Wnterland
A wiki for the life sciences where authorship matters
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus
Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus
Mutations of CASK cause an X-linked brain malformation phenotype with microcephaly and hypoplasia of the brainstem and cerebellum
Identification of loci associated with schizophrenia by genome-wide association and follow-up
Detection of sharing by descent, long-range phasing and haplotype imputation
Max-independent functions of Myc in Drosophila melanogaster
Evolutionary toggling of the MAPT 17q21.31 inversion region
A developmental framework for dissected leaf formation in the Arabidopsis relative Cardamine hirsuta
tRNA splicing endonuclease mutations cause pontocerebellar hypoplasia
Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis
Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/?-catenin signaling
ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-? bioavailability regulation
Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease
A common sequence motif associated with recombination hot spots and genome instability in humans
SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus
Victor A. McKusick 1921?2008
Nature GeneticsNature GeneticsBack to basics in Berlin
Variation in KLK genes, prostate-specific antigen and risk of prostate cancer
Reply to ?Variation in KLK genes, prostate-specific antigen and risk of prostate cancer?
High anxiety
Research highlights
Psychiatric genetics gets a boost
Casting a wider net for diabetes susceptibility genes
Hedgehog in Wnterland
A wiki for the life sciences where authorship matters
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus
Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus
Mutations of CASK cause an X-linked brain malformation phenotype with microcephaly and hypoplasia of the brainstem and cerebellum
Identification of loci associated with schizophrenia by genome-wide association and follow-up
Detection of sharing by descent, long-range phasing and haplotype imputation
Max-independent functions of Myc in Drosophila melanogaster
Evolutionary toggling of the MAPT 17q21.31 inversion region
A developmental framework for dissected leaf formation in the Arabidopsis relative Cardamine hirsuta
tRNA splicing endonuclease mutations cause pontocerebellar hypoplasia
Genome-wide association study identifies ANXA11 as a new susceptibility locus for sarcoidosis
Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/?-catenin signaling
ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-? bioavailability regulation
Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease
A common sequence motif associated with recombination hot spots and genome instability in humans
SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus
Victor A. McKusick 1921?2008
Nature GeneticsNature GeneticsNew handles on genomic structural variation
Research highlights
Kras and Hras?what is the difference?
Casting an eye on the Krebs cycle
Kidney disease and African ancestry
Pristionchus pacificus: an appropriate fondness for beetles
Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13
Common variants of FUT2 are associated with plasma vitamin B12 levels
MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity
Evidence for two independent prostate cancer risk?associated loci in the HNF1B gene at 17q12
The Pristionchus pacificus genome provides a unique perspective on nematode lifestyle and parasitism
MYH9 is associated with nondiabetic end-stage renal disease in African Americans
MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis
Integrated detection and population-genetic analysis of SNPs and copy number variation
Systematic assessment of copy number variant detection via genome-wide SNP genotyping
A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia
Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle
Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease
A canine DNM1 mutation is highly associated with the syndrome of exercise-induced collapse
Common variants at CD40 and other loci confer risk of rheumatoid arthritis
Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population
Kras regulatory elements and exon 4A determine mutation specificity in lung cancer
A robust statistical method for case-control association testing with copy number variation
Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs
Nature GeneticsNature GeneticsNew handles on genomic structural variation
Research highlights
Kras and Hras?what is the difference?
Casting an eye on the Krebs cycle
Kidney disease and African ancestry
Pristionchus pacificus: an appropriate fondness for beetles
Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13
Common variants of FUT2 are associated with plasma vitamin B12 levels
MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity
Evidence for two independent prostate cancer risk?associated loci in the HNF1B gene at 17q12
The Pristionchus pacificus genome provides a unique perspective on nematode lifestyle and parasitism
MYH9 is associated with nondiabetic end-stage renal disease in African Americans
MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis
Integrated detection and population-genetic analysis of SNPs and copy number variation
Systematic assessment of copy number variant detection via genome-wide SNP genotyping
A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia
Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle
Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease
A canine DNM1 mutation is highly associated with the syndrome of exercise-induced collapse
Common variants at CD40 and other loci confer risk of rheumatoid arthritis
Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population
Kras regulatory elements and exon 4A determine mutation specificity in lung cancer
A robust statistical method for case-control association testing with copy number variation
Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs
Nature GeneticsNature GeneticsGrains on the chessboard
Japonica rice carried to, not from, Southeast Asia
Reply to ?Rapidly evolving human promoter regions?
Reply to ?Japonica rice carried to, not from, Southeast Asia?
Rapidly evolving human promoter regions
The long shadow
Research Highlights
Photoreceptors in evolution and disease
Combing the genome for the root cause of baldness
A glorious revolution in stem cell biology
Wilms tumor and constitutional epigenetic defects
Rice, rising
EYS, encoding an ortholog of Drosophila spacemaker, is mutated in autosomal recessive retinitis pigmentosa
Susceptibility variants for male-pattern baldness on chromosome 20p11
Male-pattern baldness susceptibility locus at 20p11
TMEM70 mutations cause isolated ATP synthase deficiency and neonatal mitochondrial encephalocardiomyopathy
Structure and function of a transcriptional network activated by the MAPK Hog1
Lgr5 marks cycling, yet long-lived, hair follicle stem cells
Mutations of LRTOMT, a fusion gene with alternative reading frames, cause nonsyndromic deafness in humans
Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein
Genetic control of rice plant architecture under domestication
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer
Variant between CPT1B and CHKB associated with susceptibility to narcolepsy
Disruption of an AP-2? binding site in an IRF6 enhancer is associated with cleft lip
Constitutional 11p15 abnormalities, including heritable imprinting center mutations, cause nonsyndromic Wilms tumor
Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits
Control of a key transition from prostrate to erect growth in rice domestication
Control of rice grain-filling and yield by a gene with a potential signature of domestication
Single-copy insertion of transgenes in Caenorhabditis elegans
Corrigendum: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
Corrigendum: Mutations of CASK cause an X-linked brain malformation phenotype with microcephaly and hypoplasia of the brainstem and cerebellum
Nature GeneticsNature GeneticsGrains on the chessboard
Japonica rice carried to, not from, Southeast Asia
Reply to ?Rapidly evolving human promoter regions?
Reply to ?Japonica rice carried to, not from, Southeast Asia?
Rapidly evolving human promoter regions
The long shadow
Research Highlights
Photoreceptors in evolution and disease
Combing the genome for the root cause of baldness
A glorious revolution in stem cell biology
Wilms tumor and constitutional epigenetic defects
Rice, rising
EYS, encoding an ortholog of Drosophila spacemaker, is mutated in autosomal recessive retinitis pigmentosa
Susceptibility variants for male-pattern baldness on chromosome 20p11
Male-pattern baldness susceptibility locus at 20p11
TMEM70 mutations cause isolated ATP synthase deficiency and neonatal mitochondrial encephalocardiomyopathy
Structure and function of a transcriptional network activated by the MAPK Hog1
Lgr5 marks cycling, yet long-lived, hair follicle stem cells
Mutations of LRTOMT, a fusion gene with alternative reading frames, cause nonsyndromic deafness in humans
Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein
Genetic control of rice plant architecture under domestication
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer
Variant between CPT1B and CHKB associated with susceptibility to narcolepsy
Disruption of an AP-2? binding site in an IRF6 enhancer is associated with cleft lip
Constitutional 11p15 abnormalities, including heritable imprinting center mutations, cause nonsyndromic Wilms tumor
Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits
Control of a key transition from prostrate to erect growth in rice domestication
Control of rice grain-filling and yield by a gene with a potential signature of domestication
Single-copy insertion of transgenes in Caenorhabditis elegans
Corrigendum: Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
Corrigendum: Mutations of CASK cause an X-linked brain malformation phenotype with microcephaly and hypoplasia of the brainstem and cerebellum
Nature GeneticsNature GeneticsMultitudes of messages
Lack of support for association between common variation in TNFSF4 and myocardial infarction in a German population
Reply to ?Lack of support for association between common variation in TNFSF4 and myocardial infarction in a German population?
The genesis of genetics
Research highlights
Cell cycle micromanagement in embryonic stem cells
Nonsynonymous variants and fatty liver disease
Phenotypic variations on the theme of CNVs
Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
Gerodermia osteodysplastica is caused by mutations in SCYL1BP1, a Rab-6 interacting golgin
Lung cancer susceptibility locus at 5p15.33
Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
Common 5p15.33 and 6p21.33 variants influence lung cancer risk
Expression of 24,426 human alternative splicing events and predicted cis regulation in 48 tissues and cell lines
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation
The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos
Foxj1 transcription factors are master regulators of the motile ciliogenic program
Susceptibility loci for intracranial aneurysm in European and Japanese populations
Recurrent reciprocal 1q21.1 deletions and duplications associated with microcephaly or macrocephaly and developmental and behavioral abnormalities
Regulatory activity revealed by dynamic correlations in gene expression noise
Molecular characterization of clonal interference during adaptive evolution in asexual populations of Saccharomyces cerevisiae
Flowering-time genes modulate meristem determinacy and growth form in Arabidopsis thaliana
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes
Embryonic stem cell?specific microRNAs regulate the G1-S transition and promote rapid proliferation
Nature GeneticsNature GeneticsMultitudes of messages
Lack of support for association between common variation in TNFSF4 and myocardial infarction in a German population
Reply to ?Lack of support for association between common variation in TNFSF4 and myocardial infarction in a German population?
The genesis of genetics
Research highlights
Cell cycle micromanagement in embryonic stem cells
Nonsynonymous variants and fatty liver disease
Phenotypic variations on the theme of CNVs
Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
Gerodermia osteodysplastica is caused by mutations in SCYL1BP1, a Rab-6 interacting golgin
Lung cancer susceptibility locus at 5p15.33
Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
Common 5p15.33 and 6p21.33 variants influence lung cancer risk
Expression of 24,426 human alternative splicing events and predicted cis regulation in 48 tissues and cell lines
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer
Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation
The forkhead protein Foxj1 specifies node-like cilia in Xenopus and zebrafish embryos
Foxj1 transcription factors are master regulators of the motile ciliogenic program
Susceptibility loci for intracranial aneurysm in European and Japanese populations
Recurrent reciprocal 1q21.1 deletions and duplications associated with microcephaly or macrocephaly and developmental and behavioral abnormalities
Regulatory activity revealed by dynamic correlations in gene expression noise
Molecular characterization of clonal interference during adaptive evolution in asexual populations of Saccharomyces cerevisiae
Flowering-time genes modulate meristem determinacy and growth form in Arabidopsis thaliana
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes
Embryonic stem cell?specific microRNAs regulate the G1-S transition and promote rapid proliferation
Nature GeneticsNature GeneticsTeamwork
Without apology
Research Highlights
Evaluating signatures of sex-specific processes in the human genome
Protein demethylation required for DNA methylation
Cohort studies and the genetics of complex disease
Searching for targets of viral microRNAs
New sequence variants associated with bone mineral density
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
Common variants at 30 loci contribute to polygenic dyslipidemia
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis
Accelerated genetic drift on chromosome X during the human dispersal out of Africa
Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness
Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3? exons of TACSTD1
Somatic mutations in angiopoietin receptor gene TEK cause solitary and multiple sporadic venous malformations
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion
Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2
Variants in MTNR1B influence fasting glucose levels
Common variants in the NLRP3 region contribute to Crohn's disease susceptibility
The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation
Tandem array?based expression screens identify host mRNA targets of virus-encoded microRNAs
Nature GeneticsNature GeneticsTeamwork
Without apology
Research Highlights
Evaluating signatures of sex-specific processes in the human genome
Protein demethylation required for DNA methylation
Cohort studies and the genetics of complex disease
Searching for targets of viral microRNAs
New sequence variants associated with bone mineral density
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
Common variants at 30 loci contribute to polygenic dyslipidemia
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis
Accelerated genetic drift on chromosome X during the human dispersal out of Africa
Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness
Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3? exons of TACSTD1
Somatic mutations in angiopoietin receptor gene TEK cause solitary and multiple sporadic venous malformations
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion
Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2
Variants in MTNR1B influence fasting glucose levels
Common variants in the NLRP3 region contribute to Crohn's disease susceptibility
The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation
Tandem array?based expression screens identify host mRNA targets of virus-encoded microRNAs
Nature GeneticsNature GeneticsTeamwork
Without apology
Research Highlights
Evaluating signatures of sex-specific processes in the human genome
Protein demethylation required for DNA methylation
Cohort studies and the genetics of complex disease
Searching for targets of viral microRNAs
New sequence variants associated with bone mineral density
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
Common variants at 30 loci contribute to polygenic dyslipidemia
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis
Accelerated genetic drift on chromosome X during the human dispersal out of Africa
Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness
Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3? exons of TACSTD1
Somatic mutations in angiopoietin receptor gene TEK cause solitary and multiple sporadic venous malformations
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion
Reticular dysgenesis (aleukocytosis) is caused by mutations in the gene encoding mitochondrial adenylate kinase 2
Variants in MTNR1B influence fasting glucose levels
Common variants in the NLRP3 region contribute to Crohn's disease susceptibility
The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation
Tandem array?based expression screens identify host mRNA targets of virus-encoded microRNAs
Nature GeneticsNature GeneticsMostly, your results matter to others
Orgenic Food
Research Highlights
Integrative genetical genomics in Arabidopsis
Reverse evolution and evolutionary memory
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